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mono-ADP ribosylhydrolase 2

Summary

Gene Symbol

MACROD2

Aliases

O-acetyl-ADP-ribose deacetylase MACROD2
dJ631M13.5

Organism

Homo sapiens (human)

External Links

NCBI Gene

140733

HGNC

16126

PubChem

140733

Alliance of Genome Resources

HGNC:16126

Annotation

Keyword

3D-structure
Alternative splicing
DNA damage
Hydrolase
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
A1Z1Q3	MACRO domain-containing protein 2 O-acetyl-ADP-ribose deacetylase MACROD2 [Protein ADP-ribosylaspartate] hydrolase MACROD2 [Protein ADP-ribosylglutamate] hydrolase MACROD2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
brain development	IEA
purine nucleoside metabolic process	IBA IDA	21257746
response to bacterium	IEA
peptidyl-glutamate ADP-deribosylation	IBA IDA	23474714
cellular response to DNA damage stimulus	IBA IMP	23474712

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IDA	23474712
nucleolus	IDA
nucleoplasm	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	IDA	23474712
O-acetyl-ADP-ribose deacetylase activity
ADP-ribosylglutamate hydrolase activity	IBA IDA	23474714
deacetylase activity	IDA	21257746

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000172264

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **1 - 10** of 34 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060473	Kabuki syndrome	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0090093	hypogonadotropic hypogonadism 21 with or without anosmia	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:1059	intellectual disability	DisGeNET DisGeNET
DOID:10763	hypertension	DisGeNET
DOID:10825	essential hypertension	DisGeNET

Ortholog

Displaying entries **1 - 10** of 18 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178044	WB:WBGene00007106
Danio rerio	393521	ZFIN:ZDB-GENE-040426-1490
Xenopus laevis	398781	Xenbase:XB-GENE-5865181
Cercocebus atys	105582058		CERAT03074
Papio anubis	101014197		PAPAN13153
Gorilla gorilla gorilla	101140909		GORGO22656
Pan paniscus	100988863		PANPA21881
Pan troglodytes	735753		PANTR24387
Pongo abelii	100444213		PONAB20414
Felis catus	101096466		FELCA07401

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Acknowledgements