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transient receptor potential cation channel subfamily M member 6

Summary

Gene Symbol

TRPM6

Organism

Homo sapiens (human)

External Links

NCBI Gene

140803

PubChem

140803

Alliance of Genome Resources

HGNC:17995

Annotation

Keyword

ATP-binding
Alternative splicing
Calcium channel
Cell membrane
Disease variant
Metal-binding
Phosphoprotein
Primary hypomagnesemia
Reference proteome
Serine/threonine-protein kinase
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BX84	Channel kinase 2 Melastatin-related TRP cation channel 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IDA	17575980
monoatomic cation transmembrane transport	IBA
metal ion transport	IBA
protein phosphorylation	IEA
calcium ion transmembrane transport	IDA TAS	14576148

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

calcium ion transport [inference]

calcium ion transmembrane transport

magnesium ion transport [inference]

magnesium ion transmembrane transport

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IBA IDA	14576148
plasma membrane	IBA TAS
brush border membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	16636202 18258429
protein serine kinase activity	IEA
calcium ion transmembrane transporter activity	IDA	14576148
metal ion binding	IEA
calcium channel activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

calcium channel activity

magnesium ion transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

calcium channel activity

magnesium ion transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

calcium channel activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transient receptor potential cation channel subfamily M member

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060394	chromosome 15q13.3 microdeletion syndrome	Alliance of Genome Resources
DOID:0060883	intestinal hypomagnesemia 1	Alliance of Genome Resources
DOID:896	metal metabolism disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36694		FB:FBgn0265194
Caenorhabditis elegans	172646		WB:WBGene00001651
Mus musculus	225997		MGI:2675603	MOUSE26590
Rattus norvegicus	293874		RGD:1309942	RATNO20139
Pan troglodytes	472957	9598_0:00296e		PANTR44127
Canis lupus familiaris	484163			CANLF00422
Macaca mulatta	706119			MACMU12643
Monodelphis domestica	100020109			MONDO28721
Equus caballus	100054478			HORSE22336
Ornithorhynchus anatinus	100075204			ORNAN32617