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crystallin alpha A

Summary

Gene Symbol

CRYAA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1409

PubChem

1409

Alliance of Genome Resources

HGNC:2388

Annotation

Keyword

3D-structure
Acetylation
Cataract
Chaperone
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Eye lens protein
Glycoprotein
Metal-binding
Nucleus
Oxidation
Phosphoprotein
Reference proteome
Vision
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P02489	Heat shock protein beta-4 Heat shock protein family B member 4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
lens development in camera-type eye	IBA
visual perception	IMP	14512969 9467006
response to heat	IBA
negative regulation of intracellular transport	IDA	14752512
protein refolding	ISS

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

protein refolding

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure development [inference]

lens development in camera-type eye

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of intracellular transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

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GO Term	Evidence Code	PMID
nucleus	IDA	19464326
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	14752512 19464326 19503744 26004348 29259299 30340470
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
structural molecule activity	IDA	16303126
structural constituent of eye lens	IEA
protein binding	IPI	11700327 12235146 12601044 14752512 19651604 22085609 22153508 23188086 25416956 25910212 29892012 31515488 32296183 32814053 33961781
identical protein binding	IPI	12601044 16303126 19651604 22085609 25416956 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

structural molecule activity

structural constituent of eye lens

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heat shock protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
unfolded protein binding

Displaying **all 2** entries
InterPro
Alpha crystallin/Hsp20 domain
HSP20-like chaperone

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110266	cataract 9 multiple types	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1409	Xenbase:XB-GENE-5940571
Drosophila melanogaster	1410	FB:FBgn0011296
Caenorhabditis elegans	3315	WB:WBGene00011906
Mus musculus	12954	Xenbase:XB-GENE-5940571	MOUSE22833
Drosophila melanogaster	12955	FB:FBgn0011296
Caenorhabditis elegans	15507	WB:WBGene00011906
Xenopus tropicalis	24273	Xenbase:XB-GENE-5940571
Drosophila melanogaster	25420	FB:FBgn0011296
Drosophila melanogaster	192245	FB:FBgn0011296
Drosophila melanogaster	243912	FB:FBgn0011296

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OrthoDB (Group)

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Acknowledgements