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colony stimulating factor 1

Summary

Gene Symbol

CSF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1435

PubChem

1435

Alliance of Genome Resources

HGNC:2432

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytokine
Direct protein sequencing
Disulfide bond
Growth factor
Inflammatory response
Innate immunity
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P09603	Lanimostim Proteoglycan macrophage colony-stimulating factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
positive regulation of osteoclast differentiation	IDA	15304486
positive regulation of cell population proliferation	IDA TAS	10652277 2460758
positive regulation of monocyte differentiation	ISS	18566389
response to ischemia	IDA	8922060
mammary gland fat development	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

immune response [inference]

innate immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

leukocyte migration [inference]

myeloid leukocyte migration

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cytokine-mediated signaling pathway [inference]

macrophage colony-stimulating factor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cell population proliferation [inference]

glial cell proliferation [inference]

microglial cell proliferation

leukocyte proliferation [inference]

osteoclast proliferation

macrophage proliferation [inference]

microglial cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

developmental process involved in reproduction

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development [inference]

mammary gland fat development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

mammary duct terminal end bud growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

response to ischemia

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of microglial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of macrophage migration

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of microglial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of macrophage migration

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of glial cell migration [inference]

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of microglial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of animal organ morphogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

positive regulation of animal organ morphogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of response to macrophage colony-stimulating factor [inference]

regulation of cellular response to macrophage colony-stimulating factor stimulus [inference]

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of odontogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

regulation of odontogenesis of dentin-containing tooth [inference]

positive regulation of odontogenesis of dentin-containing tooth

positive regulation of animal organ morphogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of animal organ morphogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cytokine-mediated signaling pathway [inference]

macrophage colony-stimulating factor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of cellular response to macrophage colony-stimulating factor stimulus [inference]

regulation of macrophage colony-stimulating factor signaling pathway [inference]

positive regulation of macrophage colony-stimulating factor signaling pathway

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of microglial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of macrophage migration

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of glial cell migration [inference]

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of microglial cell migration [inference]

positive regulation of microglial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration

positive regulation of glial cell migration [inference]

positive regulation of microglial cell migration

regulation of multicellular organismal process [inference]

regulation of ossification

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

positive regulation of animal organ morphogenesis [inference]

positive regulation of odontogenesis [inference]

positive regulation of odontogenesis of dentin-containing tooth

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of macrophage differentiation [inference]

positive regulation of macrophage differentiation

regulation of monocyte differentiation [inference]

positive regulation of monocyte differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

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GO Term	Evidence Code	PMID
membrane	NAS	2460758
endoplasmic reticulum lumen	TAS
plasma membrane	IDA TAS
CSF1-CSF1R complex	ISS	19017797
extracellular region	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

CSF1-CSF1R complex

cellular anatomical entity [inference]

membrane

plasma membrane

nuclear body

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
protein binding	IPI	22153499 22483114 22826234 22902366 25416956 26235028 32296183
macrophage colony-stimulating factor receptor binding	ISS TAS	19017797 2460758
identical protein binding	IPI	22153499 22902366
cytokine activity	IBA IDA	10652277 2460758
growth factor activity	IDA	2460758

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

macrophage colony-stimulating factor receptor binding

receptor ligand activity [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

macrophage colony-stimulating factor 1

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cytokine activity
growth factor activity
osteoclast differentiation
positive regulation of macrophage differentiation

Displaying **all 2** entries
InterPro
Four-helical cytokine-like, core
Macrophage colony stimulating factor-1

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:13533	osteopetrosis	Alliance of Genome Resources
DOID:13949	interstitial cystitis	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:289	endometriosis	Alliance of Genome Resources
DOID:2921	glomerulonephritis	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:418	systemic scleroderma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12977		MGI:1339753	MOUSE38962
Rattus norvegicus	78965		RGD:621063	RATNO25389
Bos taurus	281094			BOVIN26318
Pan troglodytes	457127	9598_0:000655		PANTR22089
Canis lupus familiaris	611795			CANLF16818
Macaca mulatta	702532			MACMU22262
Danio rerio	790931		ZFIN:ZDB-GENE-061215-106
Danio rerio	100004617		ZFIN:ZDB-GENE-080204-107
Equus caballus	100146493			HORSE33587
Oryctolagus cuniculus	100338577			RABIT03603

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements