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colony stimulating factor 2 receptor subunit beta

Summary

Gene Symbol

CSF2RB

Organism

Homo sapiens (human)

External Links

NCBI Gene

1439

PubChem

1439

Alliance of Genome Resources

HGNC:2436

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32927	CDw131 GM-CSF/IL-3/IL-5 receptor common beta subunit
Q6NSJ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
granulocyte-macrophage colony-stimulating factor signaling pathway	IDA	18692472
respiratory gaseous exchange by respiratory system	TAS	9410898
cytokine-mediated signaling pathway	IBA
response to lipopolysaccharide	IEA
interleukin-3-mediated signaling pathway	IDA	8649415

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to interleukin-3 [inference]

cellular response to interleukin-3

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

regulation of leukocyte proliferation [inference]

positive regulation of leukocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
plasma membrane	IDA NAS TAS	1396555 1495999 1702217
granulocyte macrophage colony-stimulating factor receptor complex	IDA TAS	27396825 9410898

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

granulocyte macrophage colony-stimulating factor receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

granulocyte macrophage colony-stimulating factor receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	1495999 16437163 17828305 18692472 20802515 29374162 9516124
cytokine receptor activity	IBA
coreceptor activity	IDA	7957082 8649415
interleukin-5 receptor activity		9410898
signaling receptor activity	TAS	9410898

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytokine receptor common subunit beta

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12120	pulmonary alveolar proteinosis	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12983		MGI:1339759	MOUSE16723
Mus musculus	12984		MGI:1339760	MOUSE16716
Rattus norvegicus	171081		RGD:620189	RATNO37674
Pan troglodytes	458802	9598_0:005371		PANTR26477
Canis lupus familiaris	481276			CANLF01655
Xenopus laevis	495479		Xenbase:XB-GENE-6253822
Bos taurus	528530			BOVIN29957
Macaca mulatta	697508			MACMU00733
Equus caballus	100054613			HORSE26295
Danio rerio	100135062		ZFIN:ZDB-GENE-080115-1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements