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gamma-aminobutyric acid type A receptor subunit alpha 1

Summary

Gene Symbol

Gabra1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14394

PubChem

14394

Alliance of Genome Resources

MGI:95613

Annotation

Keyword

3D-structure
Cell membrane
Chloride channel
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P62812	GABA(A) receptor subunit alpha-1
Q3URD4	GABA(A) receptor subunit alpha-1
Q544F7	GABA(A) receptor subunit alpha-1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of postsynaptic membrane potential	IBA IEA
synaptic transmission, GABAergic	IBA ISO NAS	30602789
chloride transmembrane transport	IBA ISO
nervous system process
cellular response to histamine	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

signal transduction

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

multicellular organismal process [inference]

system process [inference]

nervous system process

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to organic cyclic compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane
postsynapse	IBA
postsynaptic specialization membrane	ISO ISS
cytoplasmic vesicle membrane	IEA
GABA-A receptor complex	IBA ISO ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

GABA receptor complex

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

cell junction [inference]

synapse

GABA-ergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

postsynapse

dendritic spine

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GO Term	Evidence Code	PMID
diazepam binding	ISO
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP IDA IMP	12466441
GABA-A receptor activity	IBA ISO ISS
GABA receptor activity	ISO
chloride channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

binding [inference]

protein binding

organic cyclic compound binding

diazepam binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity

GABA-A receptor activity

neurotransmitter receptor activity

benzodiazepine receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

gamma-aminobutyric acid receptor subunit alpha-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism

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Gene Ontology
GABA-A receptor activity
GABA-gated chloride ion channel activity
benzodiazepine receptor activity
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
gamma-aminobutyric acid signaling pathway
inhibitory extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity

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InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain
Gamma-aminobutyric-acid A receptor, alpha 1 subunit
Gamma-aminobutyric-acid A receptor, alpha subunit
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080431	developmental and epileptic encephalopathy 19	Alliance of Genome Resources
DOID:0111314	idiopathic generalized epilepsy 13	Alliance of Genome Resources
DOID:13413	hepatic encephalopathy	Alliance of Genome Resources
DOID:1827	idiopathic generalized epilepsy	Alliance of Genome Resources
DOID:7725	epilepsy with generalized tonic-clonic seizures	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of **114** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cyprinus carpio carpio	109046569		CYPCA133973
Cyprinus carpio carpio	109046570		CYPCA97827
Crocodylus porosus	109309972		CROPO17263
Castor canadensis	109678841	51338_0:0050b1
Mus caroli	110305133	10089_0:00340c
Mus pahari	110331497	10093_0:0034f7
Vulpes vulpes	112926565		VULVU02275
Urocitellus parryii	113187524	9999_0:001de4
Athene cunicularia	113485260		ATHCN14525
Bos indicus x Bos taurus	113895069		BOBOX24330

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements