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colony stimulating factor 2 receptor subunit beta

Summary

Gene Symbol

CSF2RB

Organism

Homo sapiens (human)

External Links

NCBI Gene

1439

PubChem

1439

Alliance of Genome Resources

HGNC:2436

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32927	CDw131 GM-CSF/IL-3/IL-5 receptor common beta subunit
Q6NSJ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
cellular response to interleukin-3	IEA
interleukin-5-mediated signaling pathway	IDA	1495999
receptor signaling pathway via JAK-STAT	IDA	18692472
immunoglobulin mediated immune response	IBA
positive regulation of leukocyte proliferation	IDA	18692472

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to interleukin-3 [inference]

cellular response to interleukin-3

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-3

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

regulation of leukocyte proliferation [inference]

positive regulation of leukocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
plasma membrane	IDA NAS TAS	1396555 1495999 1702217
granulocyte macrophage colony-stimulating factor receptor complex	IDA TAS	27396825 9410898

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

granulocyte macrophage colony-stimulating factor receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

granulocyte macrophage colony-stimulating factor receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	1495999 16437163 17828305 18692472 20802515 29374162 9516124
cytokine receptor activity	IBA
coreceptor activity	IDA	7957082 8649415
interleukin-5 receptor activity		9410898
signaling receptor activity	TAS	9410898

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytokine receptor common subunit beta

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12120	pulmonary alveolar proteinosis	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 47 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	103105584	MONDO34543
Chlorocebus sabaeus	103223258	CHLSB07269
Carlito syrichta	103258626	CARSF09335
Rhinopithecus roxellana	104682491	RHIRO04145
Macaca nemestrina	105464508	MACNE27396
Mandrillus leucophaeus	105538912	MANLE01455
Cercocebus atys	105575809	CERAT19206
Aotus nancymaae	105733761	AOTNA39046
Sarcophilus harrisii	105750684	SARHA03646
Propithecus coquereli	105805213	PROCO15866

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements