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GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3

Summary

Gene Symbol

Gabrb3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14402

PubChem

14402

Alliance of Genome Resources

MGI:95621

Annotation

Keyword

Cell membrane
Chloride channel
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P63080	GABA(A) receptor subunit beta-3
Q8C446

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
gamma-aminobutyric acid signaling pathway	ISS
gamma-aminobutyric acid signaling pathway	ISO	7893750
gamma-aminobutyric acid signaling pathway	NAS	34417930
nervous system development	IMP	9763493
brain development	IMP	16168624

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

cellular developmental process [inference]

cell development [inference]

neuron development

inner ear receptor cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

reproductive process [inference]

reproductive behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

behavior [inference]

learning or memory [inference]

rhythmic behavior [inference]

circadian behavior [inference]

circadian sleep/wake cycle process [inference]

circadian sleep/wake cycle, REM sleep

innervation

developmental process [inference]

anatomical structure development [inference]

cerebellum development

cell development [inference]

neuron development

inner ear receptor cell development

animal organ development [inference]

brain development

system development [inference]

nervous system development

cellular developmental process [inference]

cell development [inference]

neuron development

inner ear receptor cell development

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

circadian sleep/wake cycle process [inference]

circadian sleep/wake cycle, REM sleep

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to organic cyclic compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion [inference]

cellular response to zinc ion

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

response to anesthetic

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to histamine

cellular response to organonitrogen compound [inference]

cellular response to histamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to histamine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

inhibitory postsynaptic potential

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
cell surface	IDA	12183328
cytoplasmic vesicle membrane	IEA
chloride channel complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

presynapse [inference]

terminal bouton

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GO Term	Evidence Code	PMID
GABA-A receptor activity	ISS
GABA-A receptor activity	ISO	7893750
GABA-A receptor activity	IMP	9108119
GABA-A receptor activity	IBA
ion channel activity	IDA	12183328

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

binding [inference]

protein binding

identical protein binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

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Gene Ontology
GABA-A receptor activity
chemical synaptic transmission
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neurotransmitter receptor activity

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2560	FB:FBgn0010240
Drosophila melanogaster	2561	FB:FBgn0010240
Homo sapiens	2562	Xenbase:XB-GENE-6030743	HUMAN21917
Drosophila melanogaster	2563	FB:FBgn0010240
Drosophila melanogaster	2568	FB:FBgn0010240
Drosophila melanogaster	2569	FB:FBgn0010240
Drosophila melanogaster	2570	FB:FBgn0010240
Drosophila melanogaster	14400	FB:FBgn0010240
Drosophila melanogaster	14401	FB:FBgn0010240
Xenopus tropicalis	14402	Xenbase:XB-GENE-6030743

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Acknowledgements