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gap junction protein, beta 6

Summary

Gene Symbol

Gjb6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14623

PubChem

14623

Alliance of Genome Resources

MGI:107588

Annotation

Keyword

Cell membrane
Gap junction
Hearing
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3URC5
P70689	Connexin-30

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IMP	12490528
gap junction assembly	IEA ISO
negative regulation of cell population proliferation	IEA ISO
ear morphogenesis	IMP	12490528
transmembrane transport	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

intercellular transport [inference]

gap junction-mediated intercellular transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

gap junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

gap junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

gap junction assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

ear morphogenesis

sensory organ morphogenesis [inference]

ear morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

ear morphogenesis

anatomical structure development [inference]

inner ear development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to electrical stimulus

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to lipid [inference]

response to lipopolysaccharide

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

gap junction-mediated intercellular transport

transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell junction	ISO
apical plasma membrane	IEA ISO
gap junction	IDA ISO	14595769 20089884 24590285
connexin complex	IBA IEA
actin filament	IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

connexin complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

gap junction

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	14595769 16045494
actin filament binding	IEA ISO
gap junction channel activity	IBA ISO
microtubule binding	IEA ISO
beta-tubulin binding	IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

wide pore channel activity [inference]

gap junction channel activity

gap junction channel activity involved in cell communication by electrical coupling

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

tubulin binding [inference]

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0110475	autosomal recessive nonsyndromic deafness 1A	Alliance of Genome Resources
DOID:0110476	autosomal recessive nonsyndromic deafness 1B	Alliance of Genome Resources
DOID:0110565	autosomal dominant nonsyndromic deafness 3B	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:14693	Clouston syndrome	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:2121	ectodermal dysplasia	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:5154	borna disease	Alliance of Genome Resources
DOID:5199	ureteral obstruction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10804	HGNC:4288	HUMAN16477
Rattus norvegicus	84403	RGD:621830	RATNO09847
Danio rerio	404725	ZFIN:ZDB-GENE-040406-1	DANRE44549
Bos taurus	508454		BOVIN03909
Xenopus tropicalis	549738	Xenbase:XB-GENE-955798
Macaca mulatta	704105		MACMU17130
Pan troglodytes	750343		PANTR07396
Ornithorhynchus anatinus	100089296		ORNAN13630
Salmo salar	100195251		SALSA90790
Oryctolagus cuniculus	100357644		RABIT12424