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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Summary

Gene Symbol

MGAT5B

Aliases

FLJ25132
GnT-IX
GnT-VB

Organism

Homo sapiens (human)

External Links

NCBI Gene

146664

GGDB ID

gg131

HGNC

24140

mRNA

NM_144677

map

17q25.3

Protein

NP_653278

OMIM

612441

KEGG Gene ID

hsa:146664

PubChem

146664

Alliance of Genome Resources

HGNC:24140

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3V5L5	Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B GlcNAc-T Vb Mannoside acetylglucosaminyltransferase 5B N-acetylglucosaminyl-transferase Vb N-acetylglucosaminyltransferase IX

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
protein O-linked glycosylation via serine	IDA	19846580

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
manganese ion binding	IDA	19846580
protein binding	IPI	23088713
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA IDA	19846580

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg131

Gene Symbol

MGAT5B

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G39213VZ	G10219AA	12941944

Displaying **all 3** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G85856KC	G56868BH	19846580
UDP-GlcNAc	G39213VZ	G83717YJ	19846580
UDP-GlcNAc	G39213VZ	G10219AA	12941944

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G49108TO		19846580

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221136	XM_221136
Mus musculus	NP_766536	NM_172948

KEGG BRITE Database

Orthology

K09661

Name

mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]

References

12941944

Reactions

Displaying **all 6** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07625	2.4.1.-	G88380UG	G83717YJ
R07622	2.4.1.-	G39213VZ	G10219AA
R05991	2.4.1.155	G29011JC	G20030CU
R07623	2.4.1.-	G39213VZ	G88380UG
R07624	2.4.1.-	G10219AA	G83717YJ
R07621	2.4.1.-	G85856KC	G56868BH

Rhea

RHEA:16921

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.155

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:1319	brain cancer	DisGeNET
DOID:162	cancer	DisGeNET
DOID:11612	polycystic ovary syndrome	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:3571	liver cancer	DisGeNET
DOID:4450	renal cell carcinoma	DisGeNET
DOID:4451	renal carcinoma	DisGeNET
DOID:4464	collecting duct carcinoma	DisGeNET
DOID:4465	papillary renal cell carcinoma	DisGeNET
DOID:4467	clear cell renal cell carcinoma	DisGeNET

Ortholog

Displaying entries **61 - 70** of **106** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	268510	MGI:3606200	MOUSE04039
Rattus norvegicus	303693	RGD:1305188	RATNO00803
Cavia porcellus	100723796		CAVPO20165
Octodon degus	101573829		OCTDE08031
Heterocephalus glaber	101721905		HETGA13682
Melopsittacus undulatus	101878727		MELUD13491
Monodelphis domestica	100027070		MONDO14628
Pelodiscus sinensis	102454679		PELSI03835
Vombatus ursinus	114034523		VOMUR20976
Bos indicus x Bos taurus	113877903		BOBOX14500

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements