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MIRAGE

BSCL2 lipid droplet biogenesis associated, seipin

Summary

Gene Symbol

Bscl2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14705

PubChem

14705

Alliance of Genome Resources

MGI:1298392

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Lipid degradation
Lipid droplet
Lipid metabolism
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Z2E9	Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog
A0A0R4J225

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
lipid metabolic process
lipid storage	ISO
lipid storage	IMP	23458123
lipid storage	IBA
lipid droplet organization	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular developmental process [inference]

cell differentiation [inference]

maintenance of location in cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization

lipid droplet formation

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

developmental process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

cellular developmental process [inference]

cell differentiation [inference]

localization [inference]

maintenance of location [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	18585921 23458123
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA
lipid droplet	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	27806294
phospholipid binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Seipin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
lipid droplet formation
lipid droplet organization
lipid metabolic process
lipid storage

Displaying 1 entry
InterPro
Seipin family

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111136	congenital generalized lipodystrophy type 2	Alliance of Genome Resources
DOID:12336	male infertility	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100393927		CALJA04923
Macaca mulatta	100428843		MACMU11191
Ailuropoda melanoleuca	100466605		AILME06450
Pan troglodytes	100609080		PANTR03172
Cricetulus griseus	100755147		CRIGR25287
Otolemur garnettii	100946764		OTOGA04558
Pan paniscus	100994704		PANPA06911
Papio anubis	101008802		PAPAN06857
Saimiri boliviensis boliviensis	101036989		SAIBB00971
Felis catus	101091148		FELCA24996

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025