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glycine N-methyltransferase

Summary

Gene Symbol

Gnmt

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14711

PubChem

14711

Alliance of Genome Resources

MGI:1202304

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Folate-binding
Methyltransferase
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QXF8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
glycogen metabolic process	IMP	17937387
regulation of gluconeogenesis	IMP	17937387
regulation of gluconeogenesis	IBA
glycine metabolic process	ISO
methionine metabolic process	IMP	17937387

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

methylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

one-carbon metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

S-adenosylmethionine metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	ISS
cytosol	ISO
cytosol	IBA
methyltransferase complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
folic acid binding	ISO
folic acid binding	IEA
S-adenosylmethionine-dependent methyltransferase activity	ISO
glycine binding	ISO
glycine binding	IDA	15340920

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

glycine N-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

glycine N-methyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

cation binding [inference]

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

sulfur compound binding [inference]

S-adenosyl-L-methionine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Methyltransferase

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
transferase activity

Displaying 1 entry
InterPro
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111037	glycine N-methyltransferase deficiency	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	14711	ZFIN:ZDB-GENE-040227-1
Rattus norvegicus	25134	ZFIN:ZDB-GENE-040227-1	RATNO43509
Homo sapiens	27232	ZFIN:ZDB-GENE-040227-1	HUMAN84831
Sus scrofa	397444		PIGXX31581
Danio rerio	403338		DANRE13235
Pan troglodytes	462703		PANTR38185
Bos taurus	538212		BOVIN18514
Macaca mulatta	697722		MACMU34778
Oryctolagus cuniculus	100009512		RABIT02444
Monodelphis domestica	100010632		MONDO13234

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OrthoDB (Group)

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Acknowledgements