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podoplanin

Summary

Gene Symbol

Pdpn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14726

PubChem

14726

Alliance of Genome Resources

MGI:103098

Annotation

Keyword

3D-structure
Cell junction
Cell membrane
Cell projection
Cell shape
Developmental protein
Direct protein sequencing
Proteomics identification
Reference proteome
Sialic acid
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8Y5F6
Q62011	Glycoprotein 38 OTS-8 PA2.26 antigen Transmembrane glycoprotein E11

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell-cell adhesion	IMP	16869965
positive regulation of cell motility	IMP	16869965
lymphangiogenesis	IMP	12853470
lymph node development	IMP	25347465
cell population proliferation	IMP	16869965

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular process [inference]

cell adhesion

cell-cell adhesion

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell population proliferation

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

cell motility [inference]

cell migration

wound healing, spreading of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

lymphangiogenesis

anatomical structure development [inference]

lung alveolus development

animal organ development [inference]

lung development

hematopoietic or lymphoid organ development [inference]

lymph node development

visceral serous pericardium development

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport [inference]

water transport

vitamin transport [inference]

folic acid transport

organic substance transport [inference]

water transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

amino acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

amino acid transport

modified amino acid transport [inference]

folic acid transport

nitrogen compound transport [inference]

amino acid transport

amide transport [inference]

folic acid transport

modified amino acid transport [inference]

folic acid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of myofibroblast contraction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of lamellipodium organization [inference]

regulation of lamellipodium morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of biological quality [inference]

regulation of cell shape

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	23180825
cell junction	ISO
cytoplasmic vesicle	ISO ISS
membrane	ISO
anchoring junction	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane microdomain [inference]

membrane raft

cell junction

anchoring junction

cell leading edge [inference]

leading edge of lamellipodium

leading edge membrane [inference]

cell projection

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

tetraspanin-enriched microdomain

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	17616532
signaling receptor binding	ISO ISS
protein-folding chaperone binding	ISO
amino acid transmembrane transporter activity	IDA	12032185
water transmembrane transporter activity	IDA	9651190

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity

water channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

water channel activity

amide transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity

water channel activity

binding [inference]

protein binding

signaling receptor binding

cytokine binding [inference]

chemokine binding

protein-folding chaperone binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Zinc finger, RING-type

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

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Gene Ontology
Rho protein signal transduction
actin-mediated cell contraction
chemokine binding
lung development
positive regulation of cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of extracellular matrix disassembly
positive regulation of platelet aggregation
protein-folding chaperone binding
regulation of lamellipodium morphogenesis

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources
DOID:12215	oligohydramnios	Alliance of Genome Resources
DOID:2527	nephrosis	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3304	germinoma	Alliance of Genome Resources
DOID:3744	cervical squamous cell carcinoma	Alliance of Genome Resources
DOID:4440	seminoma	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:8719	in situ carcinoma	Alliance of Genome Resources
DOID:874	bacterial pneumonia	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 70 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Meriones unguiculatus	110556477	10047_0:002a8a
Vulpes vulpes	112929762		VULVU24899
Urocitellus parryii	113197796	9999_0:00397a
Bos indicus x Bos taurus	113906756		BOBOX05665
Marmota flaviventris	114105410	93162_0:003836
Grammomys surdaster	114609650	491861_0:00429d
Peromyscus leucopus	114700853	10041_0:000fa7
Mastomys coucha	116096987	35658_0:001de0
Rattus rattus	116893098	10117_0:000095
Rhinolophus ferrumequinum	117026464		RHIFE02780

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements