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KASH domain containing 5

Summary

Gene Symbol

KASH5

Organism

Homo sapiens (human)

External Links

NCBI Gene

147872

PubChem

147872

Alliance of Genome Resources

HGNC:26520

Annotation

Keyword

3D-structure
Coiled coil
Disease variant
Meiosis
Nucleus
Premature ovarian failure
Reference proteome
Telomere
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N6L0	Coiled-coil domain-containing protein 155 KASH domain-containing protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
spindle localization	IBA
spermatogenesis	IEA
oogenesis	IEA
meiotic telomere clustering	IEA
actin filament organization	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

spindle assembly

cell cycle process [inference]

spindle organization [inference]

spindle assembly

spindle localization

meiotic cell cycle process [inference]

chromosome organization involved in meiotic cell cycle [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

spindle assembly

chromosome organization [inference]

chromosome organization involved in meiotic cell cycle [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

supramolecular fiber organization [inference]

actin filament organization

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

male gamete generation [inference]

spermatogenesis

chromosome localization to nuclear envelope involved in homologous chromosome segregation

meiotic telomere clustering

meiotic cell cycle process [inference]

chromosome organization involved in meiotic cell cycle [inference]

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

chromosome localization to nuclear envelope involved in homologous chromosome segregation

meiotic telomere clustering

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

chromosome localization to nuclear envelope involved in homologous chromosome segregation

meiotic telomere clustering

organelle localization [inference]

chromosome localization [inference]

telomere localization

meiotic telomere clustering

establishment of chromosome localization [inference]

chromosome localization to nuclear envelope involved in homologous chromosome segregation

meiotic telomere clustering

spindle localization

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

chromosome localization to nuclear envelope involved in homologous chromosome segregation

meiotic telomere clustering

Displaying **all 5** entries
GO Term	Evidence Code	PMID
meiotic spindle pole	IBA
chromosome, telomeric region	IBA ISS
nuclear outer membrane	IBA
meiotic nuclear membrane microtubule tethering complex	IBA
lateral element	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

cellular anatomical entity [inference]

lateral element

spindle pole [inference]

meiotic spindle pole

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

nuclear membrane [inference]

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 27107012 32296183 33058875 33393904
dynein complex binding	IBA
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein-containing complex binding [inference]

dynein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein KASH5

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 5** entries
Gene Ontology
actin filament organization
chromosome localization to nuclear envelope involved in homologous chromosome segregation
homologous chromosome pairing at meiosis
spindle localization
telomere localization

Displaying **all 2** entries
InterPro
KASH5-like coiled-coil domain
Protein KASH5

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5426	primary ovarian insufficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	308581		RGD:1561972	RATNO17969
Mus musculus	384619		MGI:2687329	MOUSE54152
Pan troglodytes	456203	9598_0:004ec0		PANTR18910
Bos taurus	617651			BOVIN11513
Macaca mulatta	719163			MACMU18804
Callithrix jacchus	100394944			CALJA24777
Pongo abelii	100432979	9601_0:004ade		PONAB14233
Ailuropoda melanoleuca	100473873			AILME14158
Nomascus leucogenys	100598479			NOMLE00920
Canis lupus familiaris	100855738			CANLF00810

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Last updated: December 9, 2024