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zinc and ring finger 4

Summary

Gene Symbol

ZNRF4

Organism

Homo sapiens (human)

External Links

NCBI Gene

148066

PubChem

148066

Alliance of Genome Resources

HGNC:17726

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal
Transferase
Transmembrane helix
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WWF5	Nixin RING finger protein 204 RING-type E3 ubiquitin transferase ZNRF4 Zinc/RING finger protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IDA	21205830
ubiquitin-dependent protein catabolic process	IBA
protein ubiquitination	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	28656966
negative regulation of cell cycle	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of cell cycle

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing signaling pathway [inference]

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

negative regulation of cell cycle

regulation of cell cycle [inference]

negative regulation of cell cycle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
endoplasmic reticulum	IDA	28656966
endoplasmic reticulum membrane	IDA	21205830 28656966

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21205830 32296183
zinc ion binding	IEA
metal ion binding
ubiquitin protein ligase activity	IDA	28656966
ubiquitin protein ligase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

zinc finger (c3hc4-type ring finger) family protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Ortholog

Displaying entries **1 - 10** of 23 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	11342	WB:WBGene00007666
Mus musculus	20834	RGD:1563631	MOUSE20218
Caenorhabditis elegans	24017	WB:WBGene00007666
Caenorhabditis elegans	26001	WB:WBGene00007666
Caenorhabditis elegans	40791	WB:WBGene00007666
Caenorhabditis elegans	70510	WB:WBGene00007666
Caenorhabditis elegans	148066	WB:WBGene00007666
Caenorhabditis elegans	181600	WB:WBGene00007666
Rattus norvegicus	301127		RATNO42940
Caenorhabditis elegans	360554	WB:WBGene00007666

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements