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protein disulfide isomerase associated 3

Summary

Gene Symbol

Pdia3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14827

PubChem

14827

Alliance of Genome Resources

MGI:95834

Annotation

Keyword

Acetylation
Adaptive immunity
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Isomerase
Methylation
Phosphoprotein
Redox-active center
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P27773	58 kDa glucose-regulated protein 58 kDa microsomal protein Disulfide isomerase ER-60 Endoplasmic reticulum resident protein 57 Endoplasmic reticulum resident protein 60

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein folding	IBA
positive regulation of protein folding	ISO
cellular response to vitamin D	ISO
positive regulation of extrinsic apoptotic signaling pathway	IMP	15858817
adaptive immune response	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

protein folding

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

immune response [inference]

adaptive immune response

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

response to organic substance [inference]

response to organic cyclic compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

response to lipid [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

response to interleukin-7 [inference]

cellular response to interleukin-7

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
apical plasma membrane	ISO
endoplasmic reticulum lumen	TAS
MHC class I peptide loading complex	ISO
extracellular region	ISO
cell surface	IBA IDA ISO	19995400

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21093319 23395171 28437467
MHC class I protein binding	ISO
protein disulfide isomerase activity	IBA IEA
protein-disulfide reductase activity	IEA ISO
protein-disulfide reductase (glutathione) activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [inference]

protein-disulfide reductase (glutathione) activity

hydrolase activity [inference]

peptidase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

binding [inference]

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class I protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

protein disulfide-isomerase A3

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
isomerase activity
response to endoplasmic reticulum stress

Displaying **all 6** entries
InterPro
Protein disulfide-isomerase A3, first redox inactive TRX-like domain b
Protein disulfide-isomerase, thioredoxin-like domain
Protein disulphide isomerase
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:11088	asphyxia neonatorum	Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	Alliance of Genome Resources
DOID:2055	post-traumatic stress disorder	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2923		HGNC:4606	HUMAN22732
Rattus norvegicus	29468	10116_1:0013af	RGD:68430	RATNO28517
Drosophila melanogaster	36270		FB:FBgn0033663
Caenorhabditis elegans	172433		WB:WBGene00003964
Bos taurus	281803			BOVIN16862
Danio rerio	378851		ZFIN:ZDB-GENE-031002-9	DANRE27853
Xenopus tropicalis	394954		Xenbase:XB-GENE-976328
Canis lupus familiaris	478279			CANLF12459
Macaca mulatta	711029			MACMU42333
Pan troglodytes	742723			PANTR10170

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements