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cystathionine gamma-lyase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1491

PubChem

1491

Alliance of Genome Resources

HGNC:2501

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Cysteine biosynthesis
Cytoplasm
Disease variant
Lipid metabolism
Lyase
Pyridoxal phosphate
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P32929	Cysteine desulfhydrase Cysteine-protein sulfhydrase Gamma-cystathionase Homocysteine desulfhydrase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of aortic smooth muscle cell differentiation	IMP	21659522
cysteine biosynthetic process via cystathionine	IBA IDA	19428278
negative regulation of apoptotic signaling pathway	IEA
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	IDA	19019829
hydrogen sulfide biosynthetic process	IDA TAS	19019829 19428278

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

hydrogen sulfide biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

hydrogen sulfide biosynthetic process

hydrogen sulfide metabolic process [inference]

hydrogen sulfide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

hydrogen sulfide biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

cysteine metabolic process

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

hydrogen sulfide biosynthetic process

hydrogen sulfide metabolic process [inference]

hydrogen sulfide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine biosynthetic process via cystathionine

hydrogen sulfide biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasm	IBA
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protein binding	IPI	22169477 25416956 32296183
calmodulin binding	IEA
selenocystathionine gamma-lyase activity	IEA
homocysteine desulfhydrase activity	IEA
identical protein binding	IPI	16189514 25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-sulfur lyase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lyase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 4** entries
Gene Ontology
carbon-sulfur lyase activity
catalytic activity
pyridoxal phosphate binding
transsulfuration

Displaying **all 4** entries
InterPro
Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090142	cystathioninuria	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	24962		RGD:2443	RATNO24933
Drosophila melanogaster	37143		FB:FBgn0000566
Mus musculus	107869		MGI:1339968	MOUSE37158
Caenorhabditis elegans	174155		WB:WBGene00022856
Caenorhabditis elegans	180079		WB:WBGene00009048
Danio rerio	322055		ZFIN:ZDB-GENE-030131-774	DANRE37661
Xenopus tropicalis	394634		Xenbase:XB-GENE-5784449
Danio rerio	445818		ZFIN:ZDB-GENE-040905-3
Pan troglodytes	456939	9598_0:00053a		PANTR21371
Canis lupus familiaris	479991			CANLF17003

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements