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cathepsin B

Summary

Gene Symbol

CTSB

Organism

Homo sapiens (human)

External Links

NCBI Gene

1508

PubChem

1508

Alliance of Genome Resources

HGNC:2527

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5HYG5
P07858	APP secretase Cathepsin B1
A0A024R374

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	7890620 8811434
thyroid hormone generation	IEA
collagen catabolic process	IDA	22952693
epithelial cell differentiation	IEP	21492153
regulation of apoptotic process	TAS	16130169

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

regulation of molecular function [inference]

regulation of catalytic activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	ISS	22261194
extracellular space	IDA	22952693
extracellular space	IBA
lysosome	IDA	1837142 2350688

GO Hierarchy

cellular component

protein-containing complex [inference]

peptidase inhibitor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen [inference]

endolysosome lumen

endosome lumen [inference]

endolysosome lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IDA	22952693 6203523
cysteine-type endopeptidase activity	IBA
protein binding	IPI	16237761 16364318 17064696 18718938 20706999 20860624 32814053 33961781 6203523 7890620 8083219
collagen binding	IDA	22952693
peptidase activity	IDA	7890620

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding

proteoglycan binding

protein-containing complex binding [inference]

collagen binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin B

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
cysteine-type endopeptidase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 5** entries
InterPro
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9351	diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1508	Xenbase:XB-GENE-1000505
Mus musculus	13030	Xenbase:XB-GENE-1000505	MOUSE12645
Rattus norvegicus	64529		RATNO10421
Xenopus tropicalis	179053	Xenbase:XB-GENE-1000505
Danio rerio	180033	ZFIN:ZDB-GENE-070323-1
Danio rerio	180931	ZFIN:ZDB-GENE-070323-1
Bos taurus	281105		BOVIN34135
Danio rerio	406645		DANRE13111
Pan troglodytes	463993		PANTR41986
Canis lupus familiaris	486077		CANLF09927