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G protein-coupled bile acid receptor 1

Summary

Gene Symbol

GPBAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

151306

PubChem

151306

Alliance of Genome Resources

HGNC:19680

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDU6	G-protein coupled receptor GPCR19 Membrane-type receptor for bile acids hBG37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IBA
cell surface bile acid receptor signaling pathway	IDA	12419312 12524422
positive regulation of ERK1 and ERK2 cascade	IEA
cellular response to bile acid	IDA	12419312 12524422
positive regulation of cholangiocyte proliferation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

response to lipid [inference]

cellular response to lipid [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cholangiocyte proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular component organization [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	12524422
plasma membrane	TAS
plasma membrane	IDA	12419312 12524422
plasma membrane	IBA
receptor complex	IDA	12419312 12524422

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31978385
G protein-coupled bile acid receptor activity	NAS	12419312
G protein-coupled bile acid receptor activity	IDA	12524422
G protein-coupled bile acid receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled bile acid receptor activity

bile acid receptor activity [inference]

G protein-coupled bile acid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled bile acid receptor 1

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
G protein-coupled bile acid receptor activity

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	151306	Xenbase:XB-GENE-959591
Mus musculus	227289	Xenbase:XB-GENE-959591	MOUSE30525
Bos taurus	317756		BOVIN24742
Rattus norvegicus	338443	Xenbase:XB-GENE-959591	RATNO43907
Macaca mulatta	697937		MACMU05809
Pan troglodytes	741111		PANTR29756
Danio rerio	797190		DANRE45110
Oryctolagus cuniculus	100009346		RABIT12004
Monodelphis domestica	100011968		MONDO31498
Equus caballus	100055590		HORSE37670