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Hedgehog-interacting protein

Summary

Gene Symbol

Hhip

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15245

PubChem

15245

Alliance of Genome Resources

MGI:1341847

Annotation

Keyword

Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Reference proteome
Repeat
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7TN16

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
epithelial tube branching involved in lung morphogenesis	IMP	12569124
dorsal/ventral pattern formation	IGI	15576403
skeletal system morphogenesis	IMP	10050855
negative regulation of angiogenesis	NAS	15294024
negative regulation of apoptotic process	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

animal organ morphogenesis

skeletal system morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	10050855
extracellular region	IEA
cell surface	IDA	15576403

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10050855
zinc ion binding	ISO ISS
hedgehog family protein binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

hedgehog family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

hedgehog-interacting protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 6** entries
InterPro
EGF-like domain, extracellular
EGF-like domain
Folate receptor-like
Glucose/Sorbosone dehydrogenase
Six-bladed beta-propeller, TolB-like
Soluble quinoprotein glucose/sorbosone dehydrogenase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **112** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	64399		HGNC:14866	HUMAN77559
Rattus norvegicus	291936	10116_1:004fe9	RGD:1564108	RATNO15307
Danio rerio	326102		ZFIN:ZDB-GENE-030131-4827	DANRE16843
Xenopus tropicalis	448466		Xenbase:XB-GENE-487499
Pan troglodytes	461521			PANTR34570
Bos taurus	540830			BOVIN09121
Macaca mulatta	701205			MACMU35928
Monodelphis domestica	100019071			MONDO28198
Equus caballus	100062868			HORSE28232
Ornithorhynchus anatinus	100082746			ORNAN03925