GlyCosmos Portal

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
fatty-acyl-CoA binding	ISO
magnesium ion binding	ISO
magnesium ion binding	IEA
hydroxymethylglutaryl-CoA lyase activity	ISS
hydroxymethylglutaryl-CoA lyase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

hydroxymethylglutaryl-CoA lyase activity

structural molecule activity

binding [inference]

lipid binding [inference]

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

amide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

acyl-CoA binding [inference]

fatty-acyl-CoA binding

cation binding [inference]

metal ion binding

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HYDROXYMETHYLGLUTARYL-COA LYASE

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 6** entries
Gene Ontology
catalytic activity
hydroxymethylglutaryl-CoA lyase activity
ketone body biosynthetic process
leucine catabolic process
metal ion binding
oxo-acid-lyase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
HMG-CoA lyase
Pyruvate carboxyltransferase

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3155	Xenbase:XB-GENE-1002069	HUMAN48065
Xenopus tropicalis	15356	Xenbase:XB-GENE-1002069
Saccharomyces cerevisiae S288C	54511	SGD:S000002341
Rattus norvegicus	79238		RATNO32707
Bos taurus	317658		BOVIN25197
Danio rerio	394190		DANRE11672
Pan troglodytes	456624		PANTR20240
Macaca mulatta	710833		MACMU22253
Monodelphis domestica	100010594		MONDO24952
Equus caballus	100057686		HORSE27468

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements