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MIRAGE
cytochrome P450 family 1 subfamily B member 1
Summary
- Gene Symbol
-
- CYP1B1
- Aliases
-
- CP1B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Disease variant
- Fatty acid metabolism
- Glaucoma
- Heme
- Lipid metabolism
- Lyase
- Membrane
- Microsome
- Mitochondrion
- Monooxygenase
- Peters anomaly
- Reference proteome
- Steroid metabolism
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to arsenic-containing substance | ||
| cellular response to progesterone stimulus | ||
| negative regulation of NF-kappaB transcription factor activity | ||
| steroid metabolic process | ||
| response to dexamethasone |
GO Hierarchy
- response to nutrient
- response to arsenic-containing substance
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
response to organic substance [inference]
cellular response to chemical stimulus [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| intracellular membrane-bounded organelle | ||
| endoplasmic reticulum membrane | ||
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| aromatase activity | ||
| heme binding | ||
| iron ion binding | ||
| estrogen 16-alpha-hydroxylase activity | ||
| hydroperoxy icosatetraenoate dehydratase activity |
GO Hierarchy
molecular function
catalytic activity [inference]
oxidoreductase activity [inference]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Cytochrome p450
- Functional Category
-
- C: Energy production and conversion
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Cytochrome P450 superfamily |
| Cytochrome P450, E-class, group I |
| Cytochrome P450, conserved site |
| Cytochrome P450 |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060673 | Peters anomaly | |
| DOID:0080611 | anterior segment dysgenesis 6 | |
| DOID:1070 | primary open angle glaucoma | |
| DOID:10763 | hypertension | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11211 | buphthalmos | |
| DOID:11212 | hydrophthalmos | |
| DOID:11984 | hypertrophic cardiomyopathy | |
| DOID:1612 | breast cancer | |
| DOID:3458 | breast adenocarcinoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000486 | Strabismus |
| HP:0000501 | Glaucoma |
| HP:0000505 | Visual impairment |
| HP:0000523 | Subcapsular cataract |
| HP:0000525 | Abnormality iris morphology |
| HP:0000541 | Retinal detachment |
| HP:0000557 | Buphthalmos |
| HP:0000572 | Visual loss |
| HP:0000587 | Abnormal optic nerve morphology |
| Disease ID | Disease Name |
|---|---|
| OMIM:617315 |
|
| OMIM:600975 |
|
| ORPHA:98977 |
|
| OMIM:231300 |
|
| ORPHA:708 |
|
| ORPHA:98976 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 13078 | MGI:88590 | MOUSE22049 | ||
| 25426 | RGD:2460 | RATNO34963 | ||
| 459163 | 9598_0:000be8 | PANTR27430 | ||
| 483038 | CANLF05051 | |||
| 511470 | BOVIN02261 | |||
| 710385 | MACMU08781 | |||
| 100011610 | MONDO08028 | |||
| 100070088 | HORSE09336 | |||
| 100079784 | ORNAN12650 | |||
| 100150054 | ZFIN:ZDB-GENE-030902-1 | DANRE51342 |
