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hydroxysteroid 11-beta dehydrogenase 1

Summary

Gene Symbol

Hsd11b1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15483

PubChem

15483

Alliance of Genome Resources

MGI:103562

Annotation

Keyword

3D-structure
Endoplasmic reticulum
Glycoprotein
NADP
Oxidoreductase
Reference proteome
Signal-anchor
Steroid metabolism
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4JHD9	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1
P50172	11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase 11beta-HSD1A 7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1 liver-type 11-beta-HSD

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glucocorticoid biosynthetic process	ISO
steroid catabolic process	IBA
glucocorticoid catabolic process	ISO
steroid metabolic process	IEA
mineralocorticoid metabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

hormone metabolic process [inference]

mineralocorticoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

cellular process [inference]

mineralocorticoid metabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of pentose-phosphate shunt

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of generation of precursor metabolites and energy [inference]

regulation of pentose-phosphate shunt

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of amide metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of pentose-phosphate shunt

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of generation of precursor metabolites and energy [inference]

regulation of pentose-phosphate shunt

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

mineralocorticoid metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA
nuclear membrane	ISO
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

apical part of cell

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
steroid binding	ISO
steroid binding	IBA
protein homodimerization activity	ISO
protein homodimerization activity	IEA
7-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

organic cyclic compound binding [inference]

steroid binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

corticosteroid 11-beta-dehydrogenase isozyme 1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
oxidoreductase activity
steroid binding
steroid catabolic process

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR
Short-chain dehydrogenase/reductase, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090140	cortisone reductase deficiency 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3290	Xenbase:XB-GENE-960491	HUMAN54573
Xenopus tropicalis	15483	Xenbase:XB-GENE-960491
Rattus norvegicus	25116	Xenbase:XB-GENE-960491	RATNO06917
Bos taurus	282589		BOVIN08876
Ovis aries	443409		SHEEP04021
Canis lupus familiaris	449023		CANLF17102
Pan troglodytes	457698		PANTR23591
Macaca mulatta	574322		MACMU21843
Equus caballus	100056429		HORSE35502
Ornithorhynchus anatinus	100079059		ORNAN24465