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cytochrome P450 family 3 subfamily A member 7

Summary

Gene Symbol

CYP3A7

Aliases

CP37
P450-HFLA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1551

HGNC

2640

KEGG Gene ID

hsa:1551

PubChem

1551

Alliance of Genome Resources

HGNC:2640

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome
Steroid biosynthesis

Proteins

Displaying 1 entry
UniProt	Protein Name
P24462	CYPIIIA7 Cytochrome P450-HFLA P450HLp2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
retinoic acid metabolic process	IDA	11093772
lipid hydroxylation	IDA	14559847
retinol metabolic process	IEA
steroid biosynthetic process	IEA
steroid metabolic process	IBA IDA	14559847

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
retinoic acid 4-hydroxylase activity	IDA	11093772
all-trans retinoic acid 18-hydroxylase activity	IEA
estrogen 2-hydroxylase activity	IDA	12865317
steroid hydroxylase activity	IDA	14559847
oxygen binding		2722762

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

all-trans retinoic acid 18-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17691

Name

cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]

References

Rhea

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:11394	adult respiratory distress syndrome	DisGeNET DisGeNET
DOID:12716	newborn respiratory distress syndrome	DisGeNET DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:1325	bronchus cancer	DisGeNET
DOID:1380	endometrial cancer	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:2841	asthma	DisGeNET
DOID:2871	endometrial carcinoma	DisGeNET
DOID:2998	testicular cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000666
Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 7

Ortholog

Displaying entries **1 - 10** of **137** in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	174522	WB:WBGene00014254
Caenorhabditis elegans	181462	WB:WBGene00008519
Caenorhabditis elegans	184472	WB:WBGene00008809
Caenorhabditis elegans	184473	WB:WBGene00008810
Caenorhabditis elegans	187068	WB:WBGene00010606
Caenorhabditis elegans	188355	WB:WBGene00011671
Caenorhabditis elegans	188356	WB:WBGene00011672
Caenorhabditis elegans	188357	WB:WBGene00011673
Caenorhabditis elegans	188358	WB:WBGene00011674
Caenorhabditis elegans	188359	WB:WBGene00011675

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements