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cytochrome P450 family 3 subfamily A member 7

Summary

Gene Symbol

CYP3A7

Aliases

CP37
P450-HFLA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1551

HGNC

2640

KEGG Gene ID

hsa:1551

PubChem

1551

Alliance of Genome Resources

HGNC:2640

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome
Steroid biosynthesis

Proteins

Displaying 1 entry
UniProt	Protein Name
P24462	CYPIIIA7 Cytochrome P450-HFLA P450HLp2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
steroid metabolic process	IBA IDA	14559847
xenobiotic metabolic process
retinol metabolic process	IEA
steroid biosynthetic process	IEA
retinoic acid metabolic process	IDA	11093772

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
aromatase activity	IEA
estrogen 16-alpha-hydroxylase activity	IBA IDA	14559847
all-trans retinoic acid 18-hydroxylase activity	IEA
oxygen binding		2722762
estrogen 2-hydroxylase activity	IDA	12865317

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

all-trans retinoic acid 18-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K17691

Name

cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]

References

Rhea

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5082	liver cirrhosis	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000666
Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 7

Ortholog

Displaying entries **1 - 10** of **140** in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	13113	MGI:88610
Drosophila melanogaster	33056	FB:FBgn0031126
Drosophila melanogaster	35634	FB:FBgn0015038
Drosophila melanogaster	35635	FB:FBgn0015039
Drosophila melanogaster	36412	FB:FBgn0033775
Drosophila melanogaster	36666	FB:FBgn0013772
Drosophila melanogaster	37941	FB:FBgn0015040
Drosophila melanogaster	41520	FB:FBgn0038037
Drosophila melanogaster	43304	FB:FBgn0039519
Drosophila melanogaster	45556	FB:FBgn0015714

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements