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perlecan (heparan sulfate proteoglycan 2)

Summary

Gene Symbol

Hspg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15530

PubChem

15530

Alliance of Genome Resources

MGI:96257

Annotation

Keyword

3D-structure
Angiogenesis
Basement membrane
Calcium
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Heparan sulfate
Immunoglobulin domain
Laminin EGF-like domain
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
E9PZ16
Q3UHH3
Q2XQV0
Q05793
Q52KG8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
response to hypoxia
positive regulation of endothelial cell proliferation	ISO
endochondral ossification	IMP	10579729
chondrocyte differentiation	IMP	10545953

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell differentiation

chondrocyte differentiation

cell development [inference]

neuron development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

tissue development

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

regeneration [inference]

animal organ regeneration

cell development [inference]

neuron development

animal organ development [inference]

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis

system development [inference]

cellular developmental process [inference]

cell differentiation

chondrocyte differentiation

cell development [inference]

neuron development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cell population proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	IDA	10352025 10579729 11787818 11802174 12588956 15381701 15895400 15928325 18757743 7670489
Golgi lumen	TAS
extracellular matrix	IDA	10579729 15381701 16407285 23217742
collagen-containing extracellular matrix	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protease binding	IPI	22952693
calcium ion binding	IEA
protein binding	IPI	12243745 16407285 22952693 36792666
extracellular matrix structural constituent conferring compression resistance	RCA	22159717 28071719
collagen V binding	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring compression resistance

binding [inference]

protein binding

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

collagen binding [inference]

collagen V binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Basement membrane-specific heparan sulfate proteoglycan core protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
InterPro
Immunoglobulin-like domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060770	dextro-looped transposition of the great arteries	Alliance of Genome Resources
DOID:0090005	Schwartz-Jampel syndrome 1	Alliance of Genome Resources
DOID:0090032	Silverman-Handmaker type dyssegmental dysplasia	Alliance of Genome Resources
DOID:13481	thanatophoric dysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3339	Xenbase:XB-GENE-6465357	HUMAN47953
Xenopus tropicalis	15530	Xenbase:XB-GENE-6465357
Xenopus tropicalis	45320	Xenbase:XB-GENE-6465357
Xenopus tropicalis	175126	Xenbase:XB-GENE-6465357
Rattus norvegicus	313641		RATNO33334
Canis lupus familiaris	403440		CANLF07063
Bos taurus	444872		BOVIN25243
Danio rerio	565429		DANRE24960
Macaca mulatta	707213		MACMU21981
Equus caballus	100071701		HORSE27583