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5-hydroxytryptamine (serotonin) receptor 1A

Summary

Gene Symbol

Htr1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15550

PubChem

15550

Alliance of Genome Resources

MGI:96273

Annotation

Keyword

Behavior
Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q64264	Serotonin receptor 1A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
behavioral fear response	IMP	9826725
G protein-coupled receptor signaling pathway	ISO
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

ammonium ion metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

behavior [inference]

behavioral defense response [inference]

behavioral fear response

exploration behavior

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of secretion by cell [inference]

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amine transport [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway

regulation of cell communication [inference]

regulation of hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of secretion by cell [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of behavior

regulation of feeding behavior

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
dendrite	IBA
dendrite	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

axon hillock

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IEA
G-protein alpha-subunit binding	ISO
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IDA	8254366
G protein-coupled serotonin receptor activity	IMP	9826725

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

G-protein alpha-subunit binding

signaling receptor binding

receptor-receptor interaction

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2030	anxiety disorder	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Tursiops truncatus	101319989	TURTR03189
Octodon degus	101580658	OCTDE00355
Jaculus jaculus	101615412	JACJA23307
Mustela putorius furo	101671971	MUSPF08313
Heterocephalus glaber	101718872	HETGA22932
Melopsittacus undulatus	101874088	MELUD04046
Chrysemys picta bellii	101943122	CHRPI14242
Ictidomys tridecemlineatus	101971175	ICTTR01664
Chinchilla lanigera	102023540	CHILA12139
Macaca fascicularis	102120004	MACFA35591

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OrthoDB (Group)

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Acknowledgements