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5-hydroxytryptamine (serotonin) receptor 1B

Summary

Gene Symbol

Htr1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15551

PubChem

15551

Alliance of Genome Resources

MGI:96274

Annotation

Keyword

Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q0VES5	Serotonin receptor 1B
P28334	Serotonin receptor 1B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

behavior [inference]

feeding behavior

drinking behavior

tissue remodeling [inference]

bone remodeling

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

neuron cellular homeostasis [inference]

regulation of presynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to toxic substance

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to organic cyclic compound [inference]

response to cocaine

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to alcohol [inference]

response to ethanol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

negative regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

negative regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of multicellular organismal process [inference]

regulation of behavior

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	17325130
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

G protein-coupled serotonin receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

serotonergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

axon terminus [inference]

calyx of Held

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IEA
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IDA	17325130
G protein-coupled serotonin receptor activity	IBA
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

binding [inference]

small molecule binding [inference]

heterocyclic compound binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

5-hydroxytryptamine receptor 1B

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
chemical synaptic transmission
negative regulation of serotonin secretion
regulation of behavior

Displaying **all 4** entries
InterPro
5-Hydroxytryptamine 1B receptor
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of **125** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3350	WB:WBGene00004779
Homo sapiens	3351	Xenbase:XB-GENE-988006	HUMAN85544
Caenorhabditis elegans	3352	WB:WBGene00004779
Caenorhabditis elegans	3354	WB:WBGene00004779
Caenorhabditis elegans	3355	WB:WBGene00004779
Caenorhabditis elegans	15550	WB:WBGene00004779
Xenopus tropicalis	15551	Xenbase:XB-GENE-988006
Caenorhabditis elegans	15552	WB:WBGene00004779
Caenorhabditis elegans	15557	WB:WBGene00004779
Caenorhabditis elegans	24473	WB:WBGene00004779

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Acknowledgements