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5 hydroxytryptamine (serotonin) receptor 4

Summary

Gene Symbol

Htr4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15562

PubChem

15562

Alliance of Genome Resources

MGI:109246

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A494BA82	Serotonin receptor 4
P97288	Serotonin receptor 4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IDA	33299969
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-activating serotonin receptor signaling pathway	ISS
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

intestinal motility [inference]

large intestinal transit

secretion by tissue [inference]

mucus secretion

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

mucus secretion

secretion by tissue [inference]

mucus secretion

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of appetite

regulation of body fluid levels [inference]

body fluid secretion [inference]

mucus secretion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
plasma membrane	ISS
plasma membrane	IDA	33299969
plasma membrane	IBA
endosome membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

postsynapse

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
G protein-coupled serotonin receptor activity	ISS
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IDA	33299969
G protein-coupled serotonin receptor activity	IBA
protein binding	IPI	19661922

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor 4

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
chemical synaptic transmission

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8689	anorexia nervosa	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	153	FB:FBgn0038063
Drosophila melanogaster	154	FB:FBgn0038063
Drosophila melanogaster	155	FB:FBgn0038980
Homo sapiens	3360	Xenbase:XB-GENE-993770	HUMAN81601
Drosophila melanogaster	11554	FB:FBgn0038063
Drosophila melanogaster	11555	FB:FBgn0038063
Drosophila melanogaster	11556	FB:FBgn0038980
Xenopus tropicalis	15562	Xenbase:XB-GENE-993770
Drosophila melanogaster	24925	FB:FBgn0038063
Rattus norvegicus	25324	Xenbase:XB-GENE-993770	RATNO13700

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements