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solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Summary

Gene Symbol

Slc6a4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15567

PubChem

15567

Alliance of Genome Resources

MGI:96285

Annotation

Keyword

Antiport
Cell junction
Cell membrane
Cell projection
Disulfide bond
Endosome
Glycoprotein
Metal-binding
Neurotransmitter transport
Phosphoprotein
Reference proteome
Sodium
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q60857	5HT transporter Solute carrier family 6 member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
regulation of thalamus size	ISO ISS
cellular response to cGMP	IEA ISO
response to toxic substance	IEA ISO
membrane depolarization	ISO ISS
circadian rhythm	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

reproductive process [inference]

multicellular organismal reproductive process [inference]

sperm ejaculation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

memory

adult behavior [inference]

behavioral response to cocaine

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

anatomical structure development [inference]

system development [inference]

enteric nervous system development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

response to estradiol

cellular response to organic cyclic compound [inference]

cellular response to cGMP

response to lipid [inference]

response to estradiol

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

response to organophosphorus [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to oxygen-containing compound [inference]

response to estradiol

response to retinoic acid [inference]

cellular response to retinoic acid

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

neurotransmitter reuptake

serotonin uptake

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

monoamine transport

serotonin transport

serotonin uptake

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

organic hydroxy compound transport [inference]

serotonin transport

serotonin uptake

nitrogen compound transport [inference]

amino acid transport

monoamine transport

serotonin transport

serotonin uptake

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake

serotonin uptake

establishment of localization in cell [inference]

neurotransmitter reuptake

serotonin uptake

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, dopaminergic [inference]

negative regulation of synaptic transmission, dopaminergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion [inference]

positive regulation of serotonin secretion

positive regulation of monoatomic ion transport [inference]

positive regulation of serotonin secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

positive regulation of serotonin secretion

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of serotonin secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell cycle

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of serotonin secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation [inference]

negative regulation of cerebellar granule cell precursor proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, dopaminergic [inference]

negative regulation of synaptic transmission, dopaminergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation [inference]

negative regulation of cerebellar granule cell precursor proliferation

regulation of neural precursor cell proliferation [inference]

regulation of cerebellar granule cell precursor proliferation [inference]

negative regulation of cerebellar granule cell precursor proliferation

negative regulation of neural precursor cell proliferation [inference]

negative regulation of cerebellar granule cell precursor proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell cycle

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation [inference]

negative regulation of cerebellar granule cell precursor proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, dopaminergic

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of cell cycle [inference]

positive regulation of cell cycle

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

positive regulation of serotonin secretion

positive regulation of secretion by cell [inference]

positive regulation of serotonin secretion

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane depolarization

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

regulation of thalamus size

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GO Term	Evidence Code	PMID
serotonergic synapse	IEA ISO
postsynaptic membrane	IEA ISO
synapse	IBA IDA	29038237
plasma membrane	IBA ISO ISS
neuron projection	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

serotonergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
integrin binding	ISO ISS
serotonin binding	IBA ISO ISS
syntaxin-1 binding	IEA ISO
sodium ion binding	ISO ISS
antiporter activity	IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity

serotonin:sodium:chloride symporter activity

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

organic hydroxy compound transmembrane transporter activity [inference]

serotonin:sodium:chloride symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding [inference]

syntaxin-1 binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

enzyme binding [inference]

nitric-oxide synthase binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

cocaine binding

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

serotonin binding

amine binding [inference]

serotonin binding

protein-containing complex binding [inference]

organic cyclic compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 31 in total

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DO ID	Disease Name	Source
DOID:0050696	fetal alcohol spectrum disorder	Alliance of Genome Resources
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060131	alexithymia	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10933	obsessive-compulsive disorder	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:12206	dengue hemorrhagic fever	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

International Collaboration

Acknowledgements