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Standards Ontologies Notations
cytochrome P450 family 2 subfamily C member 19

Summary
Gene Symbol
  • CYP2C19
Aliases
  • CPCJ
  • P450IIC19
Organism
Homo sapiens (human)
External Links
NCBI Gene
1557
HGNC
2621
KEGG Gene ID
hsa:1557
PubChem
1557
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Direct protein sequencing
  • Fatty acid metabolism
  • Heme
  • Membrane
  • Microsome
  • Monooxygenase
  • NADP
  • Reference proteome
Proteins
Displaying 1 entry
UniProt Protein Name
P33261
  • (R)-limonene 6-monooxygenase
  • (S)-limonene 6-monooxygenase
  • (S)-limonene 7-monooxygenase
  • CYPIIC17
  • CYPIIC19
  • Cytochrome P450-11A
  • Cytochrome P450-254C
  • Fenbendazole monooxygenase (4'-hydroxylating)
  • Mephenytoin 4-hydroxylase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 6 - 7 of 7 in total
GO Term Evidence Code PMID
xenobiotic metabolic process
long-chain fatty acid metabolic process
GO Hierarchy
Displaying entries 1 - 5 of 14 in total
GO Term Evidence Code PMID
(R)-limonene 6-monooxygenase activity
oxidoreductase activity
(S)-limonene 7-monooxygenase activity
enzyme binding
long-chain fatty acid omega-1 hydroxylase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000165841

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
KEGG BRITE Database
Orthology
K17721
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
References
Rhea

RHEA:17945

O2 + (4S)-limonene
H2O + H+ + (1S,5R)-carveol
Enzyme
PMID

RHEA:18957

O2 + (4R)-limonene
H2O + H+ + (1R,5S)-carveol
Enzyme
PMID

RHEA:17149

an organic molecule + O2
H2O + H+ + an alcohol
Enzyme
PMID

RHEA:23432

O2 + (4S)-limonene
(4S)-perillyl alcohol + H2O + H+
Enzyme
PMID

RHEA:56292

O2 + fenbendazole
4'-hydroxyfenbendazole + H2O + H+
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 11 - 20 of 213 in total
DO ID Disease Name Source
DOID:0050709 early infantile epileptic encephalopathy
DOID:0050734 congenital intrinsic factor deficiency
DOID:0050811 congenital adrenal hyperplasia
DOID:0050841 focal hand dystonia
DOID:0050865 tongue squamous cell carcinoma
DOID:0060041 autism spectrum disorder
DOID:0060224 atrial fibrillation
DOID:0060262 gallbladder disease
DOID:0060891 Parkinson's disease 19A
DOID:0060895 Parkinson's disease 4
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001319
Gene Name
cytochrome P450, family 2, subfamily C, polypeptide 19
Ortholog
Displaying entries 11 - 20 of 64 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
189444 WB:WBGene00012448
32857 FB:FBgn0004959
368352 ZFIN:ZDB-GENE-050522-490
548374 Xenbase:XB-GENE-5764740
103813961 SERCA07771
103813978 SERCA07811
100933766 SARHA07497
100389947 CALJA06799
101151965 GORGO00851
100995695 PANPA05206
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024