GlyCosmos Portal

Submissions

G protein-coupled receptor kinase 3

Summary

Gene Symbol

GRK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

157

PubChem

157

Alliance of Genome Resources

HGNC:290

Annotation

Keyword

ATP-binding
Cell projection
Reference proteome
Serine/threonine-protein kinase
Synapse
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N433
P35626	Beta-adrenergic receptor kinase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
receptor internalization	IDA	20074556
protein phosphorylation	IEA
G protein-coupled receptor signaling pathway	IBA TAS
signal transduction	TAS	8427589
desensitization of G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
postsynapse	IEA
presynapse	IEA
plasma membrane	TAS
cell projection	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI	23455922 28514442 33961781
G protein-coupled receptor kinase activity	IBA
G protein-coupled receptor binding	IBA
ATP binding	IEA
beta-adrenergic receptor kinase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G protein-coupled receptor kinase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 5** entries
InterPro
AGC-kinase, C-terminal
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	25372	RGD:2063	RATNO06111
Caenorhabditis elegans	175223	WB:WBGene00001709
Bos taurus	282136		BOVIN09733
Mus musculus	320129	MGI:87941	MOUSE44859
Canis lupus familiaris	486327		CANLF10429
Danio rerio	569403	ZFIN:ZDB-GENE-030616-382	DANRE01200
Macaca mulatta	714510		MACMU01153
Drosophila melanogaster	3355013	FB:FBgn0260798
Monodelphis domestica	100009844		MONDO19222
Ornithorhynchus anatinus	100078284		ORNAN14370