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Annotation

Keyword

3D-structure
Direct protein sequencing
Fatty acid metabolism
Heme
Microsome
Mitochondrion inner membrane
Monooxygenase
NADP
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P05181	4-nitrophenol 2-hydroxylase CYPIIE1 Cytochrome P450-J

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
monoterpenoid metabolic process	IDA	16401082
epoxygenase P450 pathway	IBA
4-nitrophenol metabolic process	IDA	9348445
benzene metabolic process
carbon tetrachloride metabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

4-nitrophenol metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

xenobiotic metabolic process

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

hydrocarbon metabolic process [inference]

benzene metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

organic cyclic compound metabolic process [inference]

steroid metabolic process

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

xenobiotic metabolic process

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
mitochondrial inner membrane	ISS
cytoplasm	IBA
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity	IDA	16401082 19219744
enzyme binding	IPI	15680923
Hsp90 protein binding	ISS
long-chain fatty acid omega-1 hydroxylase activity	IDA	18577768
4-nitrophenol 2-monooxygenase activity	IDA	9348445

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

4-nitrophenol 2-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

4-nitrophenol 2-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

long-chain fatty acid omega-1 hydroxylase activity

binding [inference]

protein binding [inference]

enzyme binding

heat shock protein binding [inference]

protein-folding chaperone binding [inference]

Hsp70 protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000130649

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07415

Name

cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]

References

3782137

Rhea

RHEA:26205

H⁺ + O₂ + NADPH + 4-nitrophenol

H₂O + 4-nitrocatechol + NADP⁺

Enzyme

1.14.13.n7

PMID

9348445

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **273** in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050448	white sponge nevus	DisGeNET
DOID:0050486	exanthem	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050670	ataxic cerebral palsy	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050741	alcohol dependence	DisGeNET DisGeNET DisGeNET
DOID:0050742	nicotine dependence	DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000453
Gene Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	178704	WB:WBGene00018413
Caenorhabditis elegans	178803	WB:WBGene00019472
Caenorhabditis elegans	179148	WB:WBGene00015709
Caenorhabditis elegans	179885	WB:WBGene00007362
Caenorhabditis elegans	181850	WB:WBGene00015043
Caenorhabditis elegans	181851	WB:WBGene00015044
Caenorhabditis elegans	181852	WB:WBGene00015045
Caenorhabditis elegans	182176	WB:WBGene00015399
Caenorhabditis elegans	182177	WB:WBGene00015400
Caenorhabditis elegans	183193	WB:WBGene00007913

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements