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Annotation

Keyword

3D-structure
Direct protein sequencing
Fatty acid metabolism
Heme
Microsome
Mitochondrion inner membrane
Monooxygenase
NADP
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P05181	4-nitrophenol 2-hydroxylase CYPIIE1 Cytochrome P450-J

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
monoterpenoid metabolic process	IDA	16401082
epoxygenase P450 pathway	IBA
4-nitrophenol metabolic process	IDA	9348445
benzene metabolic process
carbon tetrachloride metabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

4-nitrophenol metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

xenobiotic metabolic process

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

hydrocarbon metabolic process [inference]

benzene metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

organic cyclic compound metabolic process [inference]

steroid metabolic process

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

4-nitrophenol metabolic process

benzene-containing compound metabolic process [inference]

benzene metabolic process

xenobiotic metabolic process

halogenated hydrocarbon metabolic process

carbon tetrachloride metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

lipid modification [inference]

lipid hydroxylation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
mitochondrial inner membrane	ISS
cytoplasm	IBA
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
aromatase activity	IEA
heme binding	IBA IDA	18818195
Hsp70 protein binding	ISS
arachidonic acid epoxygenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

4-nitrophenol 2-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

4-nitrophenol 2-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

long-chain fatty acid omega-1 hydroxylase activity

binding [inference]

protein binding [inference]

enzyme binding

heat shock protein binding [inference]

protein-folding chaperone binding [inference]

Hsp70 protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000130649

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07415

Name

cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]

References

3782137

Rhea

RHEA:26205

H⁺ + O₂ + NADPH + 4-nitrophenol

H₂O + 4-nitrocatechol + NADP⁺

Enzyme

1.14.13.n7

PMID

9348445

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying entries **131 - 140** of **273** in total

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DO ID	Disease Name	Source
DOID:2030	anxiety disorder	DisGeNET DisGeNET
DOID:2043	hepatitis B	DisGeNET
DOID:2044	drug-induced hepatitis	DisGeNET Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	DisGeNET DisGeNET
DOID:219	colon cancer	DisGeNET DisGeNET Alliance of Genome Resources
DOID:2224	essential thrombocythemia	DisGeNET
DOID:2237	hepatitis	DisGeNET DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000453
Gene Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Ortholog

Displaying entries **51 - 60** of 71 in total

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Species	Gene ID	Orthologous MAtrix
Ursus maritimus	103658635	URSMA04441
Vombatus ursinus	114028483	VOMUR31537
Bos indicus x Bos taurus	113884496	BOBOX21128
Microcebus murinus	105861495	MICMU01013
Otolemur garnettii	100958050	OTOGA00159
Chinchilla lanigera	102026028	CHILA21142
Aotus nancymaae	105732195	AOTNA40510
Ictidomys tridecemlineatus	101973029	ICTTR03939
Jaculus jaculus	101601962	JACJA21748
Myotis lucifugus	102427162	MYOLU11313

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements