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establishment of sister chromatid cohesion N-acetyltransferase 2

Summary

Gene Symbol

ESCO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

157570

PubChem

157570

Alliance of Genome Resources

HGNC:27230

Annotation

Keyword

Acyltransferase
Alternative splicing
Cell cycle
Chromosome
Disease variant
Dwarfism
Intellectual disability
Nucleus
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q56NI9	Establishment factor-like protein 2 Establishment of cohesion 1 homolog 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IEA
regulation of DNA replication	IMP	19907496
double-strand break repair	IEA
chromosome segregation	IEA
sister chromatid cohesion	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein acylation [inference]

protein acetylation [inference]

post-translational protein acetylation

post-translational protein modification [inference]

post-translational protein acetylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

protein metabolic process [inference]

protein modification process [inference]

protein acylation [inference]

protein acetylation [inference]

post-translational protein acetylation

post-translational protein modification [inference]

post-translational protein acetylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein acylation [inference]

protein acetylation [inference]

post-translational protein acetylation

post-translational protein modification [inference]

post-translational protein acetylation

macromolecule modification [inference]

protein modification process [inference]

protein acylation [inference]

protein acetylation [inference]

post-translational protein acetylation

post-translational protein modification [inference]

post-translational protein acetylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein acylation [inference]

protein acetylation [inference]

post-translational protein acetylation

post-translational protein modification [inference]

post-translational protein acetylation

cellular process [inference]

cell cycle process [inference]

chromosome segregation

sister chromatid cohesion

mitotic sister chromatid cohesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion

mitotic sister chromatid cohesion

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	19907496
chromatin	IBA
XY body	IEA
nucleus	IBA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

sex chromosome [inference]

XY body

chromocenter

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

sex chromosome [inference]

XY body

chromocenter

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IEA
protein binding	IPI	32296183
N-acetyltransferase activity	TAS
zinc ion binding	IEA
acetyltransferase activity	IDA	15958495

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity

N-acetyltransferase activity

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

peptide N-acetyltransferase activity [inference]

peptide-lysine-N-acetyltransferase activity

N-acyltransferase activity [inference]

N-acetyltransferase activity

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

peptide N-acetyltransferase activity [inference]

peptide-lysine-N-acetyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-lysine-N-acetyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-acetyltransferase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell cycle
metal ion binding
mitotic sister chromatid cohesion
peptide-lysine-N-acetyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
N-acetyltransferase ESCO, acetyl-transferase domain
N-acetyltransferase ESCO, zinc-finger

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:5325	Roberts syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	71988		MOUSE12771
Saccharomyces cerevisiae S288C	114799	SGD:S000001923
Xenopus tropicalis	157570	Xenbase:XB-GENE-5955289
Canis lupus familiaris	486098		CANLF09961
Bos taurus	538949		BOVIN34200
Rattus norvegicus	691979		RATNO10218
Macaca mulatta	713186		MACMU44445
Equus caballus	100060754		HORSE27002
Ornithorhynchus anatinus	100077762		ORNAN27039
Oryctolagus cuniculus	100341332		RABIT08094