cytochrome P450 family 11 subfamily B member 2

Summary
Gene Symbol
  • CYP11B2
Aliases
  • ALDOS
  • CPN2
  • CYP11BL
  • P-450C18
  • P450aldo
  • steroid 11-beta-monooxygenase
Organism
Homo sapiens (human)
External Links
NCBI Gene
1585
HGNC
2592
KEGG Gene ID
hsa:1585
PubChem
1585
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Disease variant
  • Heme
  • Mitochondrion inner membrane
  • Monooxygenase
  • Reference proteome
  • Steroid metabolism
  • Steroidogenesis
  • Transit peptide
Proteins
Displaying 1 entry
UniProt Protein Name
P19099
  • Aldosterone synthase
  • Aldosterone-synthesizing enzyme
  • CYPXIB2
  • Corticosterone 18-monooxygenase, CYP11B2
  • Cytochrome P-450Aldo
  • Cytochrome P-450C18
  • Steroid 11-beta-hydroxylase, CYP11B2
  • Steroid 18-hydroxylase
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000179142

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K07433
Name
steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 104 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0050459 hyperphosphatemia
DOID:0050477 Liddle syndrome
DOID:0050700 cardiomyopathy
DOID:0050811 congenital adrenal hyperplasia
DOID:0050891 adrenal cortical adenoma
DOID:0060041 autism spectrum disorder
DOID:0060224 atrial fibrillation
DOID:0060731 congenital central hypoventilation syndrome
DOID:0080326 familial hypertrophic cardiomyopathy
The Human Phenotype Ontology
Displaying entries 1 - 10 of 34 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000127 Renal salt wasting
HP:0000360 Tinnitus
HP:0000421 Epistaxis
HP:0000811 Abnormal external genitalia
HP:0000822 Hypertension
HP:0000848 Increased circulating renin level
HP:0001278 Orthostatic hypotension
HP:0001290 Generalized hypotonia
HP:0001324 Muscle weakness
Displaying all 4 entries
Disease ID Disease Name
OMIM:610600
  • corticosterone methyloxidase type 2 deficiency
OMIM:203400
  • corticosterone methyloxidase type 1 deficiency
ORPHA:556030
  • early-onset familial hypoaldosteronism
ORPHA:403
  • glucocorticoid-remediable aldosteronism
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001581
Gene Name
cytochrome P450, family 11, subfamily B, polypeptide 2

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