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cytochrome P450 family 24 subfamily A member 1

Summary

Gene Symbol

CYP24A1

Aliases

CP24
P450-CC24
lncBCAS1-4_1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1591

HGNC

2602

KEGG Gene ID

hsa:1591

PubChem

1591

Alliance of Genome Resources

HGNC:2602

Annotation

Keyword

Alternative splicing
Disease variant
Heme
Lipid metabolism
Mitochondrion
Monooxygenase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07973	Cytochrome P450 24A1 Cytochrome P450-CC24

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation	IEP	17023519
vitamin metabolic process	TAS
response to vitamin D	IDA	16720713
response to vitamin D	IBA
calcitriol biosynthetic process from calciol	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin metabolic process

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular process [inference]

signal transduction [inference]

intracellular receptor signaling pathway [inference]

vitamin D receptor signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular receptor signaling pathway [inference]

vitamin D receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HTP	34800366
mitochondrial inner membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
iron ion binding	IEA
25-hydroxycholecalciferol-24-hydroxylase activity	IDA	24893882 8679605
25-hydroxycholecalciferol-24-hydroxylase activity	IBA
heme binding	TAS	8506296
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

vitamin D 23-hydroxylase activity [inference]

vitamin D 24-hydroxylase activity [inference]

vitamin D 25-hydroxylase activity [inference]

vitamin D3 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

25-hydroxycholecalciferol-24-hydroxylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Human Protein Atlas

ENSG00000019186

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07436

Name

vitamin D3 24-hydroxylase [EC:1.14.15.16]

References

Rhea

RHEA:24988

H⁺ + O₂ + (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol

H₂O + calcitroate

Enzyme

1.14.15.16

PMID

RHEA:24968

H⁺ + O₂ + calcidiol

H₂O + secalciferol

Enzyme

1.14.15.16

PMID

RHEA:24976

H⁺ + O₂ + (1S)-1,25-dihydroxy-24-oxocalciol

H₂O + (1S)-1,23,25-trihydroxy-24-oxocalciol

Enzyme

1.14.15.16

PMID

RHEA:24972

H⁺ + O₂ + calcitetrol

H₂O + (1S)-1,25-dihydroxy-24-oxocalciol

Enzyme

1.14.15.16

PMID

RHEA:24984

H⁺ + O₂ + (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol

H₂O + (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol

Enzyme

1.14.15.16

PMID

RHEA:24964

H⁺ + O₂ + calcitriol

H₂O + calcitetrol

Enzyme

1.14.15.16

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050860	colorectal adenoma	Alliance of Genome Resources
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:12678	hypercalcemia	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3905	lung carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 14 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000103	Polyuria
HP:0000121	Nephrocalcinosis
HP:0000787	Nephrolithiasis
HP:0001252	Hypotonia
HP:0001254	Lethargy
HP:0001508	Failure to thrive
HP:0001824	Weight loss
HP:0001944	Dehydration
HP:0002013	Vomiting

Displaying 1 entry
Disease ID	Disease Name
OMIM:143880	hypercalcemia, infantile, 1

PubChem Disease

GHR Health Conditions

Idiopathic infantile hypercalcemia

MedGen Diseases

Hypercalcemia, infantile, 1

OMIM Phenotypes

HYPERCALCEMIA, INFANTILE, 1; HCINF1

KEGG Diseases

Hypercalcemia infantile

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP004331
Gene Name: cytochrome P450, family 24, subfamily A, polypeptide 1

Ortholog

Displaying entries **41 - 50** of 83 in total

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Species	Gene ID	Orthologous MAtrix
Myotis lucifugus	102432347	MYOLU11891
Astyanax mexicanus	103030576	ASTMX07460
Callorhinchus milii	103191047	CALMI05032
Chlorocebus sabaeus	103243965	CHLSB07571
Carlito syrichta	103265086	CARSF28031
Nannospalax galili	103735781	NANGA06050
Serinus canaria	103818886	SERCA13576
Rhinopithecus roxellana	104662355	RHIRO06136
Colobus angolensis palliatus	105507983	COLAP21909
Mandrillus leucophaeus	105538302	MANLE03729

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements