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cytochrome P450 family 27 subfamily B member 1

Summary

Gene Symbol

CYP27B1

Aliases

1alpha(OH)ase
25-Hydroxyvitamin D3 1alpha-hydroxylase
CYP1
Calcidiol 1-monooxygenase
P450c1
VDDR I

Organism

Homo sapiens (human)

External Links

NCBI Gene

1594

HGNC

2606

KEGG Gene ID

hsa:1594

PubChem

1594

Alliance of Genome Resources

HGNC:2606

JoGo

CYP27B1

TogoVar

CYP27B1

Annotation

Keyword

Disease variant
Heme
Lipid metabolism
Membrane
Mitochondrion
Monooxygenase
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
O15528	25-OHD-1 alpha-hydroxylase 25-hydroxyvitamin D(3) 1-alpha-hydroxylase Calcidiol 1-monooxygenase Cytochrome P450 subfamily XXVIIB polypeptide 1 Cytochrome P450C1 alpha Cytochrome P450VD1-alpha Cytochrome p450 27B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
vitamin metabolic process	TAS
calcium ion transport	ISS
negative regulation of cell population proliferation	IDA	16549446
negative regulation of calcidiol 1-monooxygenase activity	IDA	16549446
positive regulation of vitamin D 24-hydroxylase activity	IDA	16549446

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin metabolic process

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

decidualization

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to estrogen

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of small molecule metabolic process [inference]

regulation of vitamin metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of response to extracellular stimulus [inference]

regulation of response to nutrient levels [inference]

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

regulation of vitamin D 24-hydroxylase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of calcidiol 1-monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

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GO Term	Evidence Code	PMID
cytoplasm	IDA	15589699 16720713
mitochondrion	ISS
mitochondrion	TAS	9333115
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	PMID
calcidiol 1-monooxygenase activity	TAS
calcidiol 1-monooxygenase activity	IDA	15795327 16549446 17023519 22862690 9415400
calcidiol 1-monooxygenase activity	IBA
iron ion binding	IEA
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

secalciferol 1-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome P450

Functional Category

I: Lipid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
C21-steroid hormone biosynthetic process
cellular response to peptide hormone stimulus
cholesterol metabolic process
cortisol metabolic process
glucocorticoid biosynthetic process
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07438

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

References

Rhea

RHEA:49064

H⁺ + O₂ + secalciferol

H₂O + calcitetrol

Enzyme

1.14.15.18

PMID

RHEA:20573

H⁺ + O₂ + calcidiol

H₂O + calcitriol

Enzyme

1.14.15.18

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080886	vitamin D-dependent rickets type 1A	Alliance of Genome Resources
DOID:10609	rickets	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000684	Delayed eruption of teeth
HP:0000737	Irritability
HP:0000867	Secondary hyperparathyroidism
HP:0000886	Deformed rib cage
HP:0000893	Bulging of the costochondral junction
HP:0000897	Rachitic rosary
HP:0000920	Enlargement of the costochondral junction
HP:0001252	Hypotonia
HP:0001270	Motor delay

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:289157	vitamin D-dependent rickets, type 1
OMIM:264700	vitamin D-dependent rickets, type 1A

PubChem Disease

GHR Health Conditions

MedGen Diseases

Vitamin D-dependent rickets, type 1A

OMIM Phenotypes

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000490
Gene Name: cytochrome P450, family 27, subfamily B, polypeptide 1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements