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cytochrome P450 family 27 subfamily B member 1

Summary

Gene Symbol

CYP27B1

Aliases

1alpha(OH)ase
25-Hydroxyvitamin D3 1alpha-hydroxylase
CYP1
Calcidiol 1-monooxygenase
P450c1
VDDR I

Organism

Homo sapiens (human)

External Links

NCBI Gene

1594

HGNC

2606

KEGG Gene ID

hsa:1594

PubChem

1594

Alliance of Genome Resources

HGNC:2606

Annotation

Keyword

Disease variant
Heme
Lipid metabolism
Membrane
Mitochondrion
Monooxygenase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
O15528	25-OHD-1 alpha-hydroxylase 25-hydroxyvitamin D(3) 1-alpha-hydroxylase Calcidiol 1-monooxygenase Cytochrome P450 subfamily XXVIIB polypeptide 1 Cytochrome P450C1 alpha Cytochrome P450VD1-alpha Cytochrome p450 27B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 20 in total

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GO Term	Evidence Code	PMID
vitamin D catabolic process	IBA
vitamin D metabolic process	IDA TAS	9415400
regulation of bone mineralization	IMP	9415400
positive regulation of keratinocyte differentiation	IMP	12496369
calcitriol biosynthetic process from calciol	IBA IDA	15795327 16549446 17023519 22862690 9415400

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin metabolic process

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

decidualization

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to estrogen

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of small molecule metabolic process [inference]

regulation of vitamin metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of response to extracellular stimulus [inference]

regulation of response to nutrient levels [inference]

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

regulation of vitamin D 24-hydroxylase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of calcidiol 1-monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	15589699 16720713
mitochondrial outer membrane
mitochondrion	IBA ISS TAS	9333115

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA
secalciferol 1-monooxygenase activity	IDA	10518789
calcidiol 1-monooxygenase activity	IBA IDA TAS	15795327 16549446 17023519 22862690 9415400
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

secalciferol 1-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K07438

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

References

Rhea

RHEA:49064

H⁺ + O₂ + secalciferol

H₂O + calcitetrol

Enzyme

1.14.15.18

PMID

RHEA:20573

H⁺ + O₂ + calcidiol

H₂O + calcitriol

Enzyme

1.14.15.18

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET DisGeNET
DOID:10041	dysplastic nevus syndrome	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET DisGeNET
DOID:104	bacterial infectious disease	DisGeNET
DOID:10493	adrenal cortical hypofunction	DisGeNET
DOID:10573	osteomalacia	DisGeNET DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 60 in total

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HPO ID	HPO Term
HP:0001281	Tetany
HP:0001290	Generalized hypotonia
HP:0001324	Muscle weakness
HP:0001508	Failure to thrive
HP:0001510	Growth delay
HP:0001538	Protuberant abdomen
HP:0001638	Cardiomyopathy
HP:0001744	Splenomegaly
HP:0001931	Hypochromic anemia
HP:0001974	Leukocytosis

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:264700	vitamin D-dependent rickets, type 1A
ORPHA:289157	vitamin D-dependent rickets, type 1

PubChem Disease

GHR Health Conditions

MedGen Diseases

Vitamin D-dependent rickets, type 1A

OMIM Phenotypes

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000490
Gene Name: cytochrome P450, family 27, subfamily B, polypeptide 1

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173936	WB:WBGene00000375
Drosophila melanogaster	36105	FB:FBgn0033524
Drosophila melanogaster	36378	FB:FBgn0033753
Drosophila melanogaster	37163	FB:FBgn0034387
Drosophila melanogaster	40037	FB:FBgn0036806
Drosophila melanogaster	41272	FB:FBgn0037817
Drosophila melanogaster	42293	FB:FBgn0038680
Drosophila melanogaster	42294	FB:FBgn0038681
Drosophila melanogaster	246648	FB:FBgn0050489
Drosophila melanogaster	2768720	FB:FBgn0053503

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements