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cytochrome P450 family 27 subfamily B member 1

Summary

Gene Symbol

CYP27B1

Aliases

1alpha(OH)ase
25-Hydroxyvitamin D3 1alpha-hydroxylase
CYP1
Calcidiol 1-monooxygenase
P450c1
VDDR I

Organism

Homo sapiens (human)

External Links

NCBI Gene

1594

HGNC

2606

KEGG Gene ID

hsa:1594

PubChem

1594

Alliance of Genome Resources

HGNC:2606

Annotation

Keyword

Disease variant
Heme
Lipid metabolism
Membrane
Mitochondrion
Monooxygenase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
O15528	25-OHD-1 alpha-hydroxylase 25-hydroxyvitamin D(3) 1-alpha-hydroxylase Calcidiol 1-monooxygenase Cytochrome P450 subfamily XXVIIB polypeptide 1 Cytochrome P450C1 alpha Cytochrome P450VD1-alpha Cytochrome p450 27B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
calcium ion transport	ISS
negative regulation of calcidiol 1-monooxygenase activity	IDA	16549446
G1 to G0 transition	IMP	12496369
response to estrogen	IEP	15795327
response to lipopolysaccharide	IDA	12855575

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin metabolic process

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

decidualization

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to estrogen

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of small molecule metabolic process [inference]

regulation of vitamin metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of response to extracellular stimulus [inference]

regulation of response to nutrient levels [inference]

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

regulation of vitamin D 24-hydroxylase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of calcidiol 1-monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	15589699 16720713
mitochondrial outer membrane
mitochondrion	IBA ISS TAS	9333115

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA
secalciferol 1-monooxygenase activity	IDA	10518789
calcidiol 1-monooxygenase activity	IBA IDA TAS	15795327 16549446 17023519 22862690 9415400
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

secalciferol 1-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K07438

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

References

Rhea

RHEA:49064

H⁺ + O₂ + secalciferol

H₂O + calcitetrol

Enzyme

1.14.15.18

PMID

RHEA:20573

H⁺ + O₂ + calcidiol

H₂O + calcitriol

Enzyme

1.14.15.18

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	DisGeNET DisGeNET
DOID:693	dental enamel hypoplasia	DisGeNET
DOID:707	B-cell lymphoma	DisGeNET
DOID:7608	parathyroid adenoma	DisGeNET DisGeNET
DOID:768	retinoblastoma	DisGeNET
DOID:784	chronic kidney disease	DisGeNET
DOID:7997	thyrotoxicosis	DisGeNET
DOID:7998	hyperthyroidism	DisGeNET
DOID:850	lung disease	DisGeNET
DOID:8538	reticulosarcoma	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0003020	Enlargement of the wrists
HP:0003025	Metaphyseal irregularity
HP:0003029	Enlargement of the ankles
HP:0003106	Subperiosteal bone resorption
HP:0003155	Elevated circulating alkaline phosphatase concentration
HP:0003165	Elevated circulating parathyroid hormone level
HP:0003698	Difficulty standing
HP:0004322	Short stature
HP:0004492	Widely patent fontanelles and sutures
HP:0005042	Irregular, rachitic-like metaphyses

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:264700	vitamin D-dependent rickets, type 1A
ORPHA:289157	vitamin D-dependent rickets, type 1

PubChem Disease

GHR Health Conditions

MedGen Diseases

Vitamin D-dependent rickets, type 1A

OMIM Phenotypes

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000490
Gene Name: cytochrome P450, family 27, subfamily B, polypeptide 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173936	WB:WBGene00000375
Drosophila melanogaster	36105	FB:FBgn0033524
Drosophila melanogaster	36378	FB:FBgn0033753
Drosophila melanogaster	37163	FB:FBgn0034387
Drosophila melanogaster	40037	FB:FBgn0036806
Drosophila melanogaster	41272	FB:FBgn0037817
Drosophila melanogaster	42293	FB:FBgn0038680
Drosophila melanogaster	42294	FB:FBgn0038681
Drosophila melanogaster	246648	FB:FBgn0050489
Drosophila melanogaster	2768720	FB:FBgn0053503

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements