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defender against cell death 1

Summary

Gene Symbol

DAD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1603

KEGG Gene ID

hsa:1603

PubChem

1603

Alliance of Genome Resources

HGNC:2664

Annotation

Keyword

3D-structure
Acetylation
Apoptosis
Direct protein sequencing
Endoplasmic reticulum
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53G02
P61803	Defender against cell death 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA IDA NAS	31831667
negative regulation of apoptotic process	IEA
protein N-linked glycosylation via asparagine	IMP	22467853
blastocyst development	IEA
apoptotic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

developmental process [inference]

anatomical structure development [inference]

blastocyst development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of biological quality [inference]

regulation of protein stability

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS	31831667
oligosaccharyltransferase complex	IBA IDA IPI ISS NAS	22467853 31831667
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
enzyme activator activity	IMP	22467853

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000129562

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12668

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase subunit DAD1/OST2

References

15831493

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:162	cancer	DisGeNET DisGeNET
DOID:169	neuroendocrine tumor	DisGeNET
DOID:1800	neuroendocrine carcinoma	DisGeNET
DOID:2841	asthma	DisGeNET DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5409	lung small cell carcinoma	DisGeNET
DOID:9206	Barrett's esophagus	DisGeNET
DOID:9360	intrinsic asthma	DisGeNET DisGeNET
DOID:9415	allergic asthma	DisGeNET DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003139
Gene Name: defender against cell death 1

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172370	WB:WBGene00000896
Drosophila melanogaster	34159	FB:FBgn0263852
Ciona intestinalis	100186610		CIOIN06617
Callorhinchus milii	103186440		CALMI34671
Callorhinchus milii	103186441		CALMI34671
Latimeria chalumnae	102347331		LATCH00840
Danio rerio	566527	ZFIN:ZDB-GENE-060503-233	DANRE29413
Astyanax mexicanus	103040403		ASTMX21704
Astyanax mexicanus	103046192		ASTMX01957
Ictalurus punctatus	100528505		ICTPU07357

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements