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Guidelines

MIRAGE

transmembrane O-mannosyltransferase targeting cadherins 2

Summary

Gene Symbol

TMTC2

Aliases

DKFZp762A217

Organism

Homo sapiens (human)

External Links

NCBI Gene

160335

HGNC

25440

KEGG Gene ID

hsa:160335

PubChem

160335

Alliance of Genome Resources

HGNC:25440

JoGo

TMTC2

TogoVar

TMTC2

Annotation

Keyword

Endoplasmic reticulum
Proteomics identification
Reference proteome
Repeat
Signal
TPR repeat
Transferase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F8VSH2
Q8N394	Transmembrane O-mannosyltransferase targeting cadherins 2 Transmembrane and tetratricopeptide repeat-containing 2
B7Z639	Transmembrane O-mannosyltransferase targeting cadherins 2 Transmembrane and tetratricopeptide repeat-containing 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein O-linked mannosylation	IMP	28973932
protein O-linked mannosylation	IBA
calcium ion homeostasis	IMP	24764305

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	IDA	24764305
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannosyltransferase activity	IBA
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IMP	28973932
protein binding	IPI	24764305

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K23424

Name

protein O-mannosyl-transferase [EC:2.4.1.-]

References

28973932

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026