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dynein axonemal assembly factor 4

Summary

Gene Symbol

DNAAF4

Organism

Homo sapiens (human)

External Links

NCBI Gene

161582

PubChem

161582

Alliance of Genome Resources

HGNC:21493

Annotation

Keyword

Alternative splicing
Cell projection
Chromosomal rearrangement
Coiled coil
Cytoplasm
Kartagener syndrome
Neurogenesis
Nucleus
Reference proteome
Repeat
TPR repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z5Z4
Q8WXU2	Dyslexia susceptibility 1 candidate gene 1 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
regulation of intracellular estrogen receptor signaling pathway	IDA	19423554
inner dynein arm assembly	IBA IMP	23872636
learning or memory	IEA
determination of left/right symmetry	IBA IMP	23872636
outer dynein arm assembly	IBA IMP	23872636

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

epithelial cilium movement involved in extracellular fluid movement

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

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GO Term	Evidence Code	PMID
non-motile cilium	IEA
plasma membrane	IDA
extracellular region	IEA
neuron projection	IEA
nucleus	IDA	16989952 19423554

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

dynein axonemal particle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

dynein axonemal particle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19423554 20562859 23872636 25416956 26871637 28041644 29601588 32296183
nuclear estrogen receptor binding	IBA IDA	19423554

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

nuclear receptor binding [inference]

nuclear estrogen receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dynein axonemal assembly factor 4

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
determination of left/right symmetry
epithelial cilium movement involved in extracellular fluid movement
inner dynein arm assembly
nervous system development
nuclear estrogen receptor binding
outer dynein arm assembly

Displaying **all 5** entries
InterPro
CS domain
Dynein axonemal assembly factor 4, CS domain
HSP20-like chaperone
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060254	Robinow syndrome	Alliance of Genome Resources
DOID:0110615	primary ciliary dyskinesia 25	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:4428	dyslexia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 70 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oreochromis niloticus	100711870		ORENI69296
Cavia porcellus	100724579		CAVPO11473
Cricetulus griseus	100769043		CRIGR00167
Sarcophilus harrisii	100914764		SARHA10112
Otolemur garnettii	100957907		OTOGA16341
Pan paniscus	100995246	9597_0:003c5b	PANPA13413
Saimiri boliviensis boliviensis	101033300		SAIBB25487
Felis catus	101085981		FELCA13737
Ovis aries	101122030		SHEEP18226
Gorilla gorilla gorilla	101126613	9595_0:0040d8	GORGO10583

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements