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dynein axonemal assembly factor 4

Summary

Gene Symbol

DNAAF4

Organism

Homo sapiens (human)

External Links

NCBI Gene

161582

PubChem

161582

Alliance of Genome Resources

HGNC:21493

Annotation

Keyword

Alternative splicing
Cell projection
Chromosomal rearrangement
Coiled coil
Cytoplasm
Kartagener syndrome
Neurogenesis
Nucleus
Reference proteome
Repeat
TPR repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z5Z4
Q8WXU2	Dyslexia susceptibility 1 candidate gene 1 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
regulation of intracellular estrogen receptor signaling pathway	IDA	19423554
inner dynein arm assembly	IBA IMP	23872636
learning or memory	IEA
determination of left/right symmetry	IBA IMP	23872636
outer dynein arm assembly	IBA IMP	23872636

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

epithelial cilium movement involved in extracellular fluid movement

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular steroid hormone receptor signaling pathway [inference]

regulation of intracellular estrogen receptor signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
non-motile cilium	IEA
plasma membrane	IDA
extracellular region	IEA
neuron projection	IEA
nucleus	IDA	16989952 19423554

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

dynein axonemal particle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

dynein axonemal particle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19423554 20562859 23872636 25416956 26871637 28041644 29601588 32296183
nuclear estrogen receptor binding	IBA IDA	19423554

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

nuclear receptor binding [inference]

nuclear estrogen receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dynein axonemal assembly factor 4

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
determination of left/right symmetry
epithelial cilium movement involved in extracellular fluid movement
inner dynein arm assembly
nervous system development
nuclear estrogen receptor binding
outer dynein arm assembly

Displaying **all 5** entries
InterPro
CS domain
Dynein axonemal assembly factor 4, CS domain
HSP20-like chaperone
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060254	Robinow syndrome	Alliance of Genome Resources
DOID:0110615	primary ciliary dyskinesia 25	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:4428	dyslexia	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Callorhinchus milii	103187189	CALMI03698
Carlito syrichta	103266910	CARSF12906
Cynoglossus semilaevis	103392525	CYNSE11756
Ursus maritimus	103676772	URSMA15420
Nannospalax galili	103745711	NANGA13168
Serinus canaria	103815990	SERCA10281
Pteropus vampyrus	105294295	PTEVA14248
Takifugu rubripes	105418493	TAKRU00388
Cercocebus atys	105601117	CERAT11357
Aotus nancymaae	105729145	AOTNA34788

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements