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OTU deubiquitinase 7A

Summary

Gene Symbol

OTUD7A

Organism

Homo sapiens (human)

External Links

NCBI Gene

161725

PubChem

161725

Alliance of Genome Resources

HGNC:20718

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Methylation
Nucleus
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TE49	Zinc finger protein Cezanne 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein deubiquitination	TAS
protein K48-linked deubiquitination
protein K63-linked deubiquitination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IBA
protein K11-linked deubiquitination	IDA	23827681

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytosol	TAS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
DNA binding	IEA
cysteine-type deubiquitinase activity	IBA IDA TAS	23827681
K63-linked polyubiquitin modification-dependent protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding [inference]

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding [inference]

K63-linked polyubiquitin modification-dependent protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

OTU domain-containing protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
K63-linked polyubiquitin modification-dependent protein binding
hydrolase activity
metal ion binding
zinc ion binding

Displaying **all 2** entries
InterPro
OTU domain
Zinc finger, A20-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060394	chromosome 15q13.3 microdeletion syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	170711		MGI:2158505	MOUSE51420
Caenorhabditis elegans	171633		WB:WBGene00021733
Rattus norvegicus	309252		RGD:1563721	RATNO16325
Pan troglodytes	453287	9598_0:003e21		PANTR09849
Danio rerio	559455		ZFIN:ZDB-GENE-100212-1	DANRE27748
Macaca mulatta	720680			MACMU41589
Xenopus tropicalis	779462		Xenbase:XB-GENE-1012996
Bos taurus	789946			BOVIN16556
Monodelphis domestica	100021938			MONDO08623
Equus caballus	100060048			HORSE16485

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OrthoDB (Group)

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Acknowledgements