GlyCosmos Portal

Submissions

interleukin 6 receptor, alpha

Summary

Gene Symbol

Il6ra

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16194

PubChem

16194

Alliance of Genome Resources

MGI:105304

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P22272	IL-6R 1
A0A0G2JGF1
Q3URV7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
positive regulation of interleukin-6 production	IEA ISO
developmental growth	ISO
positive regulation of MAPK cascade	ISO
positive regulation of chemokine production	IEA ISO
positive regulation of tyrosine phosphorylation of STAT protein	ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

multicellular organismal process [inference]

cytokine production [inference]

vascular endothelial growth factor production

developmental process [inference]

anatomical structure development [inference]

endocrine pancreas development

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

growth [inference]

developmental growth

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of collagen biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of collagen metabolic process [inference]

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

negative regulation of collagen biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell proliferation involved in kidney development [inference]

positive regulation of glomerular mesangial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

receptor signaling pathway via STAT

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell proliferation involved in kidney development [inference]

positive regulation of glomerular mesangial cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of cell proliferation involved in kidney development [inference]

regulation of glomerular mesangial cell proliferation [inference]

positive regulation of glomerular mesangial cell proliferation

positive regulation of cell proliferation involved in kidney development [inference]

positive regulation of glomerular mesangial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell proliferation involved in kidney development [inference]

positive regulation of glomerular mesangial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA ISO
interleukin-6 receptor complex	IDA ISO	27893700
ciliary neurotrophic factor receptor complex	IEA ISO
extracellular space	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell body membrane [inference]

neuronal cell body membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
enzyme binding	IEA ISO
cytokine receptor activity	ISO
interleukin-6 binding	IBA ISO
interleukin-6 receptor activity	IDA ISO	27893700
ciliary neurotrophic factor binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-6 receptor binding

growth factor receptor binding [inference]

interleukin-6 receptor binding

growth factor binding [inference]

enzyme binding

cytokine binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-6 receptor subunit alpha

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytokine-mediated signaling pathway

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying entries **1 - 10** of 18 in total

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DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0050847	sleep apnea	Alliance of Genome Resources
DOID:0080545	hyper IgE syndrome	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 72 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Jaculus jaculus	101606800	51337_0:004a23
Mustela putorius furo	101676719		MUSPF01332
Heterocephalus glaber	101704925	10181_0:0046c7
Mesocricetus auratus	101825858	10036_0:0023ae
Ictidomys tridecemlineatus	101959639	43179_0:001b93	ICTTR01358
Microtus ochrogaster	101981880	79684_0:003f86
Chinchilla lanigera	102022428	34839_0:00487d	CHILA23292
Latimeria chalumnae	102359769		LATCH13322
Peromyscus maniculatus bairdii	102908743	230844_0:0022c6
Chlorocebus sabaeus	103223920		CHLSB08377

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements