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signal peptide peptidase like 2C

Summary

Gene Symbol

SPPL2C

Organism

Homo sapiens (human)

External Links

NCBI Gene

162540

PubChem

162540

Alliance of Genome Resources

HGNC:28902

JoGo

SPPL2C

TogoVar

SPPL2C

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Protease
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IUH8	Intramembrane protease 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
acrosome assembly	ISS
membrane protein ectodomain proteolysis	IMP	17965014
intracellular calcium ion homeostasis	ISS
fusion of sperm to egg plasma membrane involved in single fertilization	ISS
membrane protein intracellular domain proteolysis	IMP	16829952

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition

cellular process involved in reproduction in multicellular organism [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

secretory granule organization [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

reproductive process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm-egg recognition

developmental process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IBA
endoplasmic reticulum membrane	IDA	16829952
Golgi-associated vesicle membrane	IBA
lumenal side of endoplasmic reticulum membrane	IDA	15385547
lumenal side of endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

Golgi-associated vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

Golgi-associated vesicle membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
aspartic endopeptidase activity, intramembrane cleaving	ISS
aspartic endopeptidase activity, intramembrane cleaving	IBA
protein homodimerization activity	IDA	15385547
molecular adaptor activity	IEA