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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
integrin alpha 2
Summary
- Gene Symbol
-
- Itga2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Calcium
- Cell adhesion
- Disulfide bond
- Glycoprotein
- Integrin
- Magnesium
- Metal-binding
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q62469 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell-matrix adhesion | ||
| cell-cell adhesion | ||
| cellular response to mechanical stimulus | ||
| positive regulation of collagen biosynthetic process | ||
| positive regulation of transmission of nerve impulse |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| axon terminus | ||
| basal part of cell | ||
| focal adhesion | ||
| presynapse |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| integrin binding | ||
| protein-containing complex binding | ||
| collagen binding involved in cell-matrix adhesion | ||
| metal ion binding | ||
| collagen receptor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- integrin alpha-2
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cell adhesion mediated by integrin |
| cell-matrix adhesion |
| integrin binding |
| integrin-mediated signaling pathway |
| metal ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060573 | von Willebrand's disease 1 | |
| DOID:0060574 | von Willebrand's disease 2 | |
| DOID:0060903 | thrombosis | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:11758 | iron deficiency anemia | |
| DOID:13241 | Behcet's disease | |
| DOID:1588 | thrombocytopenia | |
| DOID:1727 | retinal vein occlusion | |
| DOID:2219 | Glanzmann's thrombasthenia | |
| DOID:2349 | arteriosclerosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 3673 | HGNC:6137 | HUMAN79123 | ||
| 36692 | FB:FBgn0286785 | |||
| 170921 | RGD:621632 | RATNO23651 | ||
| 281872 | BOVIN15951 | |||
| 397483 | PIGXX10586 | |||
| 471550 | PANTR35584 | |||
| 489208 | CANLF14958 | |||
| 703572 | MACMU39004 | |||
| 100031498 | MONDO16238 | |||
| 100063367 | HORSE20153 |
