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integrin beta 2

Summary

Gene Symbol

Itgb2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16414

PubChem

16414

Alliance of Genome Resources

MGI:96611

Annotation

Keyword

Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Phagocytosis
Phosphoprotein
Proteomics identification
Pyrrolidone carboxylic acid
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q542I8
P11835	Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta Complement receptor C3 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IBA ISO NAS	19693543
cell-cell adhesion	IGI ISO	12652296 16093349
amyloid-beta clearance	IMP	20199584
positive regulation of leukocyte adhesion to vascular endothelial cell	IMP	24458438
positive regulation of superoxide anion generation	ISO

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

amyloid-beta clearance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	19299737
membrane	IDA	10601245 23395392
plasma membrane raft	ISO
focal adhesion	IBA
receptor complex	ISO	23382219

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

membrane raft

plasma membrane raft

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	19234461 23395392
integrin binding	IBA
protein-containing complex binding	ISO
complement component C3b binding	IGI	20199584
heat shock protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

heat shock protein binding

cell adhesion molecule binding

integrin binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

integrin binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

integrin beta-2

Functional Category

P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
amyloid-beta binding
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway
phagocytosis

Displaying **all 10** entries
InterPro
Integrin beta N-terminal
Integrin beta subunit, VWA domain
Integrin beta subunit, cytoplasmic domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin beta-2 superfamily
Integrin domain superfamily
PSI domain
von Willebrand factor A-like domain superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0110910	leukocyte adhesion deficiency 1	Alliance of Genome Resources
DOID:10952	nephritis	Alliance of Genome Resources
DOID:12297	Vogt-Koyanagi-Harada disease	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:2938	Epstein-Barr virus infectious disease	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:4481	allergic rhinitis	Alliance of Genome Resources
DOID:552	pneumonia	Alliance of Genome Resources
DOID:6612	leukocyte adhesion deficiency	Alliance of Genome Resources
DOID:820	myocarditis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3689		HGNC:6155	HUMAN58930
Drosophila melanogaster	44885		FB:FBgn0004657
Caenorhabditis elegans	175504		WB:WBGene00003930
Bos taurus	281877			BOVIN15506
Rattus norvegicus	309684	10116_1:0053d7	RGD:1305581	RATNO22151
Sus scrofa	396943			PIGXX06285
Canis lupus familiaris	403770			CANLF12946
Pan troglodytes	458607			PANTR25835
Danio rerio	557797		ZFIN:ZDB-GENE-110411-4	DANRE44700
Macaca mulatta	710577			MACMU30710

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements