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integrin beta 5

Summary

Gene Symbol

Itgb5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16419

PubChem

16419

Alliance of Genome Resources

MGI:96614

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G5E8F8
O70309
Q6PE70

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IBA ISO NAS	19693543
cell-cell adhesion	IBA
endodermal cell differentiation
stress fiber assembly	IBA IMP ISO	24036928
cell adhesion mediated by integrin	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

epithelial cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cellular component assembly [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
integrin alphav-beta5 complex	IDA ISO	20826760
focal adhesion	IBA IDA	18794329
receptor complex	ISO	23382219
cell leading edge	IDA	18794329
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphav-beta5 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell leading edge

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	24997346
integrin binding	IBA IPI	20826760 8601592
signaling receptor binding
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

integrin binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

integrin beta-5

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 8** entries
InterPro
Integrin beta N-terminal
Integrin beta subunit, VWA domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin beta, epidermal growth factor-like domain 1
Integrin domain superfamily
von Willebrand factor A-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Astyanax mexicanus	103047818		ASTMX08643
Callorhinchus milii	103176393		CALMI10153
Nannospalax galili	103741999	1026970_0:002b11	NANGA00809
Rhinopithecus roxellana	104655400		RHIRO16731
Fukomys damarensis	104858139	885580_0:00319f
Pteropus vampyrus	105297528		PTEVA16720
Macaca nemestrina	105470255		MACNE19844
Cercocebus atys	105589795		CERAT26702
Aotus nancymaae	105731913		AOTNA36903
Propithecus coquereli	105808035		PROCO00849

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements