GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
NADP
Oxidoreductase
Proteomics identification
Reference proteome
Steroid metabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P52895	3-alpha-HSD3 Chlordecone reductase homolog HAKRD Dihydrodiol dehydrogenase 2 Dihydrodiol dehydrogenase/bile acid-binding protein Type III 3-alpha-hydroxysteroid dehydrogenase
B4DK69

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IDA	18508192
digestion	IDA	8573067
doxorubicin metabolic process	IBA IMP	20837989
daunorubicin metabolic process	IBA IMP	20837989
positive regulation of cell population proliferation	IDA	18508192

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

secondary metabolic process [inference]

polyketide metabolic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

lipid metabolic process [inference]

steroid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

olefinic compound metabolic process [inference]

progesterone metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

multicellular organismal process [inference]

digestion

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

response to lipid [inference]

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to alcohol [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to ketone [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

response to oxygen-containing compound [inference]

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

response to alcohol [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to ketone [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
androstan-3-alpha,17-beta-diol dehydrogenase activity	IEA
carboxylic acid binding	IDA	8573067
alditol:NADP+ 1-oxidoreductase activity	IBA IDA	21232532
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	20837989
ketosteroid monooxygenase activity	IBA IDA	21232532

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

indanol dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

monocarboxylic acid binding [inference]

bile acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

monocarboxylic acid binding [inference]

bile acid binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000151632

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00089

Name

3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]

References

Rhea

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:20381

androsterone + NAD⁺

H⁺ + 5α-androstan-3,17-dione + NADH

Enzyme

1.1.1.209

PMID

RHEA:34783

a 3α-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

PMID

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:16729

(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:22400

androstan-3α,17β-diol + NAD⁺

H⁺ + NADH + 17β-hydroxyandrostanone

Enzyme

1.1.1.53

PMID

RHEA:16321

(S)-indan-1-ol + NADP⁺

H⁺ + indan-1-one + NADPH

Enzyme

1.1.1.112

PMID

RHEA:34779

a 3α-hydroxysteroid + NAD⁺

H⁺ + a 3-oxosteroid + NADH

Enzyme

PMID

RHEA:20377

androsterone + NADP⁺

H⁺ + 5α-androstan-3,17-dione + NADPH

Enzyme

1.1.1.209

PMID

RHEA:42004

5α-androstane-3α,17β-diol + NAD⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADH

Enzyme

1.1.1.53

PMID

RHEA:65220

(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:16317

(S)-indan-1-ol + NAD⁺

H⁺ + indan-1-one + NADH

Enzyme

1.1.1.112

PMID

4397102

Disease

Disease Ontology

Displaying entries **1 - 10** of 94 in total

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DO ID	Disease Name	Source
DOID:0050639	primary cutaneous amyloidosis	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0090091	hypogonadotropic hypogonadism 23 with or without anosmia	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET

The Human Phenotype Ontology

Displaying **all 5** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000037	Male pseudohermaphroditism
HP:0000062	Ambiguous genitalia
HP:0012245	Sex reversal

Displaying 1 entry
Disease ID	Disease Name
OMIM:614279	46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

PubChem Disease

MedGen Diseases

46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

OMIM Phenotypes

46,XY SEX REVERSAL 8; SRXY8

KEGG Diseases

46,XY gonadal dysgenesis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006739
Gene Name: aldo-keto reductase family 1, member C2

Ortholog

Displaying entries **1 - 10** of 35 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175047	WB:WBGene00012722
Drosophila melanogaster	39305	FB:FBgn0036183
Danio rerio	326033	ZFIN:ZDB-GENE-030131-4758
Xenopus laevis	379255	Xenbase:XB-GENE-6256353
Xenopus laevis	779224	Xenbase:XB-GENE-5844251
Xenopus tropicalis	448368	Xenbase:XB-GENE-5757727
Xenopus tropicalis	779650	Xenbase:XB-GENE-5844204
Xenopus tropicalis	100127714	Xenbase:XB-GENE-5895911
Ornithorhynchus anatinus	100085065		ORNAN04476
Macaca fascicularis	101865536		MACFA41893

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements